Akukho unyango lwe-MCAS. Kukho, nangona kunjalo, indlela esekelwe ngokufanelekileyo eyenza iimpawu phantsi kolawulo olunentsingiselo kwinani elikhulu lezigulana.
Ulawulo lwakhiwe kwiintsika ezimbini - ukunciphisa oko kucaphukisa iiseli zemast, kunye nokuzinzisa indlela abaphendula ngayo ngokulula. Ayisebenzi kakuhle ngaphandle komnye.
Isakhelo
Umgaqo wesibini kukuba izilingo zifuna ixesha. Izizinzisi zeeseli zeMast ngakumbi zinokuthatha iiveki ukubonisa isiphumo sazo esipheleleyo, kwaye ukuziyeka kwangoko yindlela eqhelekileyo yokulahla into ebinokusebenza. Ulingo olumalunga neeveki ezine ukuya kwezintandathu ngotshintsho ngumgaqo osoloko ucatshulwa, nangona ixesha elifanelekileyo lihluka ngokwe-arhente kunye nesigwebo sikagqirha.
Ulawulo lwakhiwe kwiintsika ezimbini - ukunciphisa oko kucaphukisa iiseli zemast, kunye nokuzinzisa indlela abaphendula ngayo ngokulula. Ayisebenzi kakuhle ngaphandle komnye.
Umgaqo olawulayo kukunyuka kwamanyathelo. Unyango ngokubanzi luqala ngowona mngcipheko usekiweyo nowona uphantsi, ubambe ixesha elide ngokwaneleyo ukuba ugwebe ngokunyanisekileyo, kwaye longeza ezinye ii-arhente kuphela xa zifuneka.Ukuqala amayeza amaninzi ngaxeshanye kuyahenda xa iimpawu zinzima, kodwa yenza ukuba isiphumo singachazeki - ukuba izinto ziyaphucuka, akukho mntu waziyo ukuba loluphi utshintsho olunoxanduva, kwaye ukuba kukho into ebangela ukusabela, akukho mntu waziyo ukuba makayeke.
Inqanaba lokuqala - H1 antihistamines. Isizukulwana sesibini se-H1 blockers sisiqalo esiqhelekileyo, esikhethiweyo kwiprofayili yecala elifanelekileyo. Bajongana neempawu eziqhutywa yi-histamine uninzi lwezigulana eziqaphela kuqala: ukurhawuzelelwa, ukugungxulwa, ukurhawuzelela, kunye nerhinitis. Abanye oogqirha basebenzisa iidosi ezingaphezulu kwedosi yokwaliwa eqhelekileyo kwisifo seeseli zemast, eso sisigqibo somntu omiselweyo kunomcimbi wokuzilungisa.
Inqanaba lesibini - ukongeza i-H2 antihistamines. I-Histamine isebenza kwiintlobo ezingaphezu kweyodwa ye-receptor, kwaye i-H2 i-receptors igxininiswe kwi-gastrointestinal tract. Ukuvala i-H1 kunye ne-H2 kunye rhoqo kuvelisa ulawulo olungcono kunoko uwedwa, ngakumbi kwi-reflux, isicaphucaphu, kunye neempawu zesisu ezishiya ii-arhente ze-H1 zingabanjwanga.
Inqanaba lesithathu - i-mast cell stabilizers. Endaweni yokuthintela umphumo wabalamli abakhululweyo, ezi zijolise ekunciphiseni ukukhululwa kwindawo yokuqala. I-Cromolyn sodium kunye ne-ketotifen zizinto ezisetyenziswa rhoqo. Ziyacotha ukwenza, zifuna iiveki zokusetyenziswa rhoqo ngaphambi kokuba inzuzo ibonakale, kwaye i-cromolyn kwifom yomlomo isebenza ikakhulu emathunjini.
Inqanaba lesine - i-leukotriene inhibitors kunye nee-agent ezongezelelweyo. Ngenxa yokuba i-leukotrienes igalelo kwiimpawu zokuphefumula kunye nesisu esingenakufikelelwa yi-antihistamines, i-leukotriene receptor antagonists yongezwa rhoqo. Ngaphaya kweli nqaku, ulawulo luya kumhlaba ohluka kakhulu sisigulana kunye neengcali, kubandakanya i-aspirin ye-prostaglandin-mediated flushing kwizigulana ezikhethiweyo, kunye nonyango lwe-biologic olufana ne-omalizumab kwiimeko eziphikisayo.Ezi zithwala imingcipheko enentsingiselo kunye nezithintelo ezithile kwaye zixhomekeke ngokuqinileyo kwingcali.
Yonke i-arhente echazwe apha inikezelwa njengendlela yoqhelaniso kwindlela epapashiweyo - kungekhona njengengcebiso. Idosi, ulandelelwano, ukusebenzisana, kunye nokufaneleka kuxhomekeke kwimbali yomntu, kunye nezigqibo zokumisela zezogqirha wakho.
Yonke i-arhente echazwe apha inikezelwa njengendlela yoqhelaniso kwindlela epapashiweyo - kungekhona njengengcebiso. Idosi, ulandelelwano, ukusebenzisana, kunye nokufaneleka kuxhomekeke kwimbali yomntu, kunye nezigqibo zokumisela zezogqirha wakho.
Izigulana zihlala zixela ukuba ukuthoba umthamo opheleleyo we-trigger kuninzi kubo njengalo naliphi na iyeza elinye. Ezi zimbini zisebenza kunye - ulawulo lwe-pharmacological luphakamisa umda, ukunciphisa i-trigger igcina umthwalo wemihla ngemihla phantsi kwayo.
Umgaqo wokupakisha ukusuka Izichukumisi isebenza ngqo apha. Kuba ukwenza kusebenze kubonakalisa umthwalo owongezelekayo, ukususa nokuba ziziphithiphithi ezimbalwa ezithembekileyo kunokudala i-headroom eyaneleyo yokuba ukuvezwa okuqhelekileyo kuyeke ukubangela ukusabela. Oku kuhlala kulapho ezona nzuzo zibonakalayo zakuqala zivela khona.
Amanyathelo asebenzayo aphinda avele kwiiakhawunti zesigulana aquka ukugcina ubushushu bendawo yokuhlala buzinzile, ukukhetha iimveliso ezingenavumba, ukubeka phambili ukutya okutsha ngaphezu kokutya okudala okanye okugcinwe ixesha elide, ukukhusela ukulala, kunye nokwakha umthambo kancinci kancinci kancinci kunokuwushiya. Akukho nanye kwezi ephawulekayo ngokwayo; kunye batshintsha isiseko.
Izigulana zihlala zixela ukuba ukuthoba umthamo opheleleyo we-trigger kuninzi kubo njengalo naliphi na iyeza elinye. Ezi zimbini zisebenza kunye - ulawulo lwe-pharmacological luphakamisa umda, ukunciphisa i-trigger igcina umthwalo wemihla ngemihla phantsi kwayo.
Kuyafaneleka ukubiza igama lomgibe ngokuthe ngqo: kunokwenzeka ukunciphisa izinto ezibangela ukuba kube nzima ukuba ubomi buvumelane phantse nantoni na. Irejimeni ephelisa ukusabela ngokuphelisa umsebenzi, isikolo, ukutya okwahlukahlukeneyo, nokunxibelelana nabanye iye yatshintsha enye indlela yokwenzakala kwenye. Injongo yobona bomi buphangaleleyo kwiphysiology yakho iya kuxhasa, hayi obona bomi buncinci bunqanda iimpawu.
Kuyafaneleka ukubiza igama lomgibe ngokuthe ngqo: kunokwenzeka ukunciphisa izinto ezibangela ukuba kube nzima ukuba ubomi buvumelane phantse nantoni na. Irejimeni ephelisa ukusabela ngokuphelisa umsebenzi, isikolo, ukutya okwahlukahlukeneyo, nokunxibelelana nabanye iye yatshintsha enye indlela yokwenzakala kwenye. Injongo yobona bomi buphangaleleyo kwiphysiology yakho iya kuxhasa, hayi obona bomi buncinci bunqanda iimpawu.
Ukhuseleko
Isicwangciso senyathelo likaxakeka esibhaliweyo, ekuvunyelwene ngaso nogqirha wakho, sisenzo esiqhelekileyo. Ifanele imisele iimpawu ezilumkiso ezaziwayo, into emayisetyenziswe, nini, kunye nexesha lokutsalela umnxeba kwiinkonzo zikaxakeka. Iikopi ezinikwe usapho, abantu osebenza nabo, okanye abasebenzi besikolo zithetha ukuba abantu abakungqongileyo banokwenza ukuba awukwazi.
Ezinye izigulana ezinesifo semast cell zisemngciphekweni we-anaphylaxis-intshukumo ekhawulezayo, ebukhali, enokuthi ibeke esichengeni ubomi. Apho loo mngcipheko usebenza khona, ukuyicwangcisa akuyonto yokuzikhethela, kwaye yincoko onokuthi ube nayo nogqirha wakho phambi kokuba ifuneke kunangexesha.
Izigulana ezivavanywe ukuba zisemngciphekweni ngokuqhelekileyo zimiselwe i-epinephrine auto-injection kwaye ziyalelwe ukuba ziziphathe rhoqo. I-epinephrine yonyango lokuqala lwe-anaphylaxis; i-antihistamines ayithathi indawo yayo kwaye akufanele ixhomekeke kwi-reaction ebukhali.
Eli candelo lichaza izenzo jikelele kwaye alinakuthatha indawo yesicwangciso esakhiwe malunga nembali yakho. Ukuba awuzange uxoxe ngesicwangciso sikaxakeka kunye nogqirha wakho, loo ncoko ifanelekile ukuba uyicele kwidinga lakho elilandelayo.
Umbono wexesha elide
Inkqubela ibonakala lula xa ilinganiswa. Ukulandelela uphawu kunye nobukhulu, iintsuku zomsebenzi ezilahlekileyo, kunye nobubanzi boluhlu lwakho olunyamezelekayo lunika uphawu olucacileyo kunememori - kwaye imemori ayithembekanga kumacala omabini ngexesha lobunzima obunzima.
I-MCAS yimeko engapheliyo kwaye ulawulo lwangoku luneempawu kunokuba lunyange. Ukubeka okulindelweyo ngokunyanisekileyo ekuqaleni kwenza inkqubo ibe lula ukuyigcina.
Ngomfanekiso opheleleyo weklinikhi, kubandakanywa iimpawu zenkqubo yelungu, imbonakalo yophando, kunye nemithombo ekhankanyiweyo, bona Isikhokelo seMCAS seMfundo. Ukufumana inkxaso evela kubantu abaphila nemeko efanayo, yethu ziyindawo elungileyo ukuqala.