Pamberi pezvinokonzeresa, kuongororwa, kana kurapwa zvine musoro, imwe pfungwa inofanirwa kutanga yamhara: muMCAS dambudziko harisi mangani maseru mast aunawo - ndiko kuti vanopisa moto nyore nyore.
Mast cells haasi muvengi. Ndiyo imwe yezvishandiso zvechinyakare uye zvinobatsira zvakanyanya - ndosaka zvichinyanya kukosha kana vakatadza.
Mast cell imhando yewhite blood cell inogara munyama pane kutenderera muropa zvakasununguka. Zvinotora kugara pese apo muviri wako unosangana nenyika yekunze - ganda, nzira dzemhepo, gut lining, uye matishu akatenderedza tsinga netsinga. Kuiswa ikoko nemaune. Mast cells ndevamiriri, vakaiswa kumiganhu.
Imwe neimwe yakarongedzwa nemagranules: madiki ekuchengetedza mavhesi akabata ekare akagadzirwa makemikari nhume, kana varevereri. Kana sero remast raona kutyisidzira kwechokwadi, rinodzikira - richirasa vaya vanoyananisa munyama yakatenderedza mukati memasekondi. Mitsipa yeropa inowedzera, mvura inopinda mukati, tsinga dzinopisa, uye masero ekudzivirira muviri anoshevedzwa. Izvo zvaunosangana nazvo sekuzvimba, kukwenya, kana mhino inomhanya ndiyo inooneka mupendero weiyo nzira inoshanda seyakagadzirwa.
Izvi zvinobatsira biology. Mast cell anobatsira kurwisa zvipembenene, huturu hwakajeka mushure mekuruma, kuronga kuporeswa kweronda, uye kuchengetedza chipingamupinyi pakati pako nenzvimbo yako. Mune hutano hwehutano hwekudzivirira hutachiwana hwakajeka: vanopindura kune kutyisidzira chaiko muchiyero, uye vobva vanyarara.
Iyo yakakosha ruzivo rwekunzwisisa MCAS kumhanya. Mast cell haadi kugadzira mhinduro yavo - yakatotakurwa uye yakamirira. Ndizvo zvinoita kuti maitiro avo akurumidze kudaro, uye chii chinoita kuti kushanya kusina kukodzera kuve kwakaoma kugara nako.
Mast cell density ndiyo yakakwirira pamiganhu yemuviri. Uku kugovera kunotsanangura chikonzero nei zviratidzo zveMCAS zvisingawanzo kugara munzvimbo imwechete.
MuMast Cell Activation Syndrome, maseru mast anowanikwa munhamba dzakajairwa uye anotaridzika zvakanaka. Chakachinja chikumbaridzo chavo. Dzinomutsa pazvisingafanire kuita - zvechimbichimbi, kana mukupindura zvinokurudzira izvo zvinofanirwa kunge zvisingashamisi, sekuchinja kwetembiricha, hwema, chikafu, kana kurovedza muviri kwakajairika.
Mhedzisiro yacho haisi chiratidzo chimwe chete asi muenzaniso. Nekuti varevereri vanoburitswa kuita matishu mumuviri wese, uye nekuti avo vanoyananisa vanoita patsinga dzeropa, tsinga, mhasuru yakatsetseka, uye mamwe maseru edziviriro, chikamu chimwe chete chinogona kuburitsa kuyerera, moyo wekumhanya, kurwadziwa kwemudumbu, mhute yehuropi, uye kupfupika kwekufema panguva imwe chete.Kumurapi asina kujairana nehosha yemast cell, musanganiswa uyu unogona kutaridzika sematambudziko akati wandei anoitika kamwechete.
Zvinhu zviviri zvinotsanangura chirwere chekiriniki. Kutanga, zviratidzo episodic uye inodzokororwa - vanouya mumafungu pane kuti varambe vakatsiga. Chechipiri, ndivo multisystem - anosanganisira maviri kana anopfuura masisitimu enhengo pamwechete. Murwere ane zviratidzo zvakavharirwa kune imwechete sisitimu uye asingambochinjika haagone kuve neMCAS.
Panewo chikumbaridzo chinoitwa nevarwere vanoziva nguva refu chisati chatsanangurwa kwavari. Maonero anoshivirira ega ega anogona kusanganisa kumutsa maitiro - imba inodziya yega yakanaka, girazi rewaini chete rakanaka, asi izvo zviviri pamwechete hazvisi. Ichi ndicho chikonzero MCAS ichiwanzoita senge isingafungidzike kubva kunze uku ichitevera inopindirana yemukati logic.
"MCAS chirwere chemaitiro asina kufanira mast cell activation inotungamira kune boka renyeredzi rezviratidzo zvinogara zvichidzokororwa mumasystem akawanda enhengo."
- Valent et al., International Archives of Allergy uye Immunology, 2012
Kwakawanda kwekuvhiringidzika kwakatenderedza MCAS kunobva kumamiriro akafanana nayo. Kuvapatsanura kunojekesa izvo zvinorehwa nechirwere ichi.
Haisi mastocytosis. Mune mastocytosis, muviri unounganidza akawandisa maseru maseru, uye izvo zvakawandisa zvinogona kuoneka - mumwongo biopsy, mumaronda eganda, kana mune inoenderera yakasimudzwa yekutanga tryptase. MuMCAS kuverenga kwakajairwa. Uyu ndiwo mutsauko umwechete wakanyanya kukosha, ndosaka MCAS yakaoma kuratidza: hapana huwandu hwesero husina kujairika hwekunongedza.
Hakusi kungofanana neallergies. Yechinyakare allergy imhinduro yeIgE-yakakwenenzverwa kune chimwe chinhu, chinozivikanwa, uye inogadzirwazve - kuratidzwa kwakafanana kunoburitsa maitiro akafanana, uye kuongororwa kweallergy kunoiwana. Kuita kweMCAS kazhinji kusiri kwe-IgE-mediated, kunowanzo kukonzereswa nekukurudzira kwemuviri sekupisa kana kudzvanywa kwete nemapuroteni, uye kazhinji kudzosa mhedzisiro yakaipa pamapanera akajairwa allergy.Varwere vazhinji vanosvika paMCAS chaizvo nekuti kuongororwa kweallergy kwakadzoka kwakachena asi zviratidzo zvavo zvisina.
Hakusi kufunganya. Kuburitswa kwemurevereri zvechokwadi kunoburitsa moyo wekumhanya, pfungwa yekuradzika, kufema, uye mhute yekuziva - iyo siginecha yefiziology yekuvhunduka kurwiswa, kunobva muimmunology kwete psychology. Varwere vanogaroudzwa kuti dambudziko nderepfungwa chirwere che mast cell chisati chatariswa.Kuzvidya mwoyo kunogona kugarisana neMCAS, uye kurarama nechirwere chisingatsanangurike chisingaperi kunoburitsa zvimwe, asi hazviverengere zvakawanikwa zvine chinangwa sekutsvaira, mikoko, kana kukwirira kwemuyananisi.
Haisi kuongororwa kwekusabatanidzwa kwakachena. Kunyange zvazvo mamwe mamiriro achifanira kubviswa, MCAS yakaburitsa nzira yekubvumirana inoda imwe chiratidzo chechiratidzo, humbowo hwekusunungurwa kwemuyananisi, uye mhinduro kune mast-cell-inotungamirwa kurapwa. Kuongororwa kwakanaka kune zvinodiwa pachezvayo, kwete zvinongosara kana dzimwe bvunzo dzisina kunaka.
Huwandu hwakatendeseka hwehuwandu hweMCAS hausati hwavapo. Mamiriro acho akaratidzirwa zviri pamutemo muna 2007 chete, nzira yekubvumirana yakateverwa muna 2010 na2012, uye maitiro ekuongorora anoramba achisiyana zvakanyanya pakati penyanzvi uye pakati penyika. Zvakaburitswa fungidziro dzinosiyana zvakanyanya, uye huwandu hwakakura ndihwo huchawanikwa - hunoratidza kusavimbika kwechokwadi kwete nhamba yakagadziriswa.
Izvo zvinyorwa zvinotsanangura nechivimbo zvakanyanya chimiro chehuwandu hwevarwere. MCAS inowanikwa kakawanda muvakadzi kupfuura varume. Zviratidzo zvinowanzotanga mukuyaruka kana kuti munhu mukuru, kunyange zvazvo zvinotanga pazera ripi neripi zvichishumwa. Varwere vazhinji vanotsanangura nhoroondo yehupenyu hwese yekuve neyakajairika reactive iyo inozongozoronga gare gare kuva maitiro anozivikanwa.
MCAS inofambawo nekambani. Inoshumwa pamwe chete ne hypermobile Ehlers-Danlos syndrome uye mamwe anobatanidza tishu kusagadzikana, uye pamwe nedysautonomia kusanganisira POTS. Kunyangwe izvi zvinomiririra nzira yakagovaniswa yepasi kana kupindirana nzira dzekutumira mubvunzo wakavhurika wekutsvaga kwete chokwadi chakagadziriswa - asi nekiriniki, varwere vanouya nemumwe vakakodzera kuongororwa kune vamwe.
Kunyanya kuenderana kuwanikwa mumaakaundi evarwere hurefu hwenzira yekuongororwa. Nekuda kwekuti zviratidzo zvinoyambuka miganhu yehunyanzvi, varwere vanowanzoendeswa kune dzakatevedzana nyanzvi - gastroenterology, dermatology, cardiology, allergy, psychiatry - mumwe nemumwe anoongorora dunhu rimwe redambudziko rehurongwa. Makore anowanzopfuura munhu asati abatanidza mufananidzo wacho wose.
Kunzwisisa nzira ndiyo nheyo. Zvinhu zvitatu zvinotevera zvinovaka zvakananga pairi.
Zvikonzero inovhara izvo chaizvo zvinobvisa maseru mast - iwo mapoka ekuratidzwa anowanzo batanidzwa, nei kusimudzira kwemuviri senge kupisa uye kumanikidza zvinhu zvakanyanya sezvinhu zvakamwiwa, uye kuti chikumbaridzo mhedzisiro inotsanangura sei maitiro anoita seasina kurongeka.
Kuongororwa inofamba nenzira yekubvumirana, miedzo yemurevereri inobatanidzwa uye zvavanoda zvakanyanya kubata, uye nei migumisiro yakaipa ichizivikanwa kunyange kune varwere vane chirwere chechokwadi.
Kurapa inotsanangura humbowo-based management approaches, kubva pakushandisa zvishoma nezvishoma antihistamines uye mast cell stabilizers kusvika kune trigger-reduction strategy iyo varwere vanowanzowana kuita zvakanyanya kusimudza.
Kuti uwane mufananidzo wakazara mugwaro rimwe chete - kusanganisira zviratidzo neorgan system, nzvimbo yekutsvagisa, uye zvizere zvinotemerwa - ona MCAS Dzidzo gwara.