Chii Inosimudzira
Mast Cells
Sei Zvichikonzera Stack
Iro zano rimwechete rinonyanya kubatsira pakutarisira MCAS nderekuti activation inowanda. Mast sero anopindura kune yakazara mutoro, kwete kune chinhu chimwe chete pane rondedzero.
Varwere vanowanzotsanangura maitiro avo sevasingafungidziriki. Kunyatsoongorora kunowanzoratidza chimwe chinhu chakarongeka: zvakawanda zvinoshivirirwa zvinosvika pedyo zvakakwana pamwe chete kuti zviyambuke pachikumbaridzo icho pasina angadai akayambuka ari ega. Imba inopisa inogoneka. Girazi rewaini tsvuku rinogoneka. Vhiki rinoshungurudza rinogoneka. Vose vari vatatu manheru mamwe chete havasi.
Ichi ndicho chikonzero nzira dzekubvisa dzinovhima chikafu chine mhosva kazhinji kazhinji dzinokundikana. Kubvisa chinhu chimwe chete kunoderedza mutoro wose zvishoma, zviratidzo zvinovandudza zvishoma, uye murwere anopedzisa - zvine musoro asi zvisiri izvo - kuti vakawana mhinduro. Kuputika kunotevera kunobva kwasvika pasina chikonzero chiri pachena, nekuti chikonzero chaive chakaunganidzwa pane chero chikamu chimwe chete.
Zvimwe zviviri zvivakwa zvinoita kuti zvinokonzeresa zviome kupinza pasi. Magadzirirwo anogona kudaro kunonoka, kuonekwa maawa mushure mekuratidzwa kwete pakarepo, izvo zvinoparadzanisa hukama huri pakati pechikonzero nemigumisiro. Uye yemunhu trigger set anogona kuchinja nekufamba kwenguva, kuwedzera munguva dzekutadza kutonga uye kazhinji kuderera zvakare kana kurapwa kunounza yekutanga reactivity pasi.
Chirevo chinoshanda ndechekuti chiziviso chetrigger chiri pamusoro pemapateni kwete chiitiko chimwe chete. Chinoratidza chinokonzeresa chinyorwa chinochengetwa kwemavhiki, kwete mhedziso inotorwa kubva kune rimwe zuva rakaipa.
Zvenyama & Environmental
Zvinokonzeresa zvenyama ndiyo chikamu chinowanzo potsa, nekuti hachisanganisi chinhu chinopinda mumuviri zvachose. Mast maseru anopindura kune mechanic uye yekupisa inosimudzira zvakananga - ndosaka yakajairwa allergy kuyedzwa, yakavakirwa kutenderedza kuona mapuroteni, hapana chaanowana.
Tembiricha iri pakati peinonyanya kushumwa. Kupisa, kutonhora, uye kukurumidza kuchinja pakati pavo zvose zvinogona kukonzera activation. Mvura inopisa, saunas, kushanduka kwemamiriro ekunze kamwe kamwe, uye kufamba pakati pemhepo yekufemesa nemhepo yezhizha inhoroondo dzakajairika.
Kumanikidza uye kupokana paganda rinogona kubudisa maitiro anooneka. Dermographism - apo kupuruzira kwakasimba kweganda kunosimudza welt pamutsara wekubata - chiratidzo chinocherechedzwa, uye zvipfeko zvinosunga, bhandi muchiuno, uye tambo dzepamapfudzi zvinogona kukwana.
Exertion ndicho chikonzero chechokwadi chevarwere vazhinji, uye chimwe chine mutengo chaiwo wehupenyu, sezvo kurovedza muviri kuchibatsira neimwe nzira. Kusimba uye mwero wekuwedzera zvinonyanya kukosha kupfuura nguva, ndosaka zvishoma nezvishoma, yakaderera-kusimba nzira dzinowanzo bvumidzwa zviri nani.
Kukurudzira Kunoda
Hapana Chinhu
Zvokudya & Histamine
Zvekudya zvinokonzeresa muMCAS zvinowanzova nezve histamine zvirimo uye mast cell kushatirwa kwete chekirasi yechikafu allergy - mutsauko une mhedzisiro chaiyo yemabatirwo ekudya.
Histamine inoungana muchikafu kana ichikura, ichivirisa, kana kuchengetwa. Zvokudya zvachembera, zvakarapwa, zvakaviriswa, kana kungosiiwa mufiriji kwemazuva akati wandei zvinotakura zvakawanda. Ichi ndicho chikonzero kutsva kunowanzokosha kupfuura iyo chaiyo musanganiswa: hove imwe chete inogona kutenderwa zvakanaka pazuva rainotengwa uye nekusatenderwa mazuva matatu gare gare.
Boka rechipiri, dzimwe nguva rinodaidzwa kuti histamine liberators, chikafu chinoita sechikurudzira mast cells kuburitsa histamine yavo pane kuzvipa zvakawanda ivo pachavo. Chetatu chinobatsira kuburikidza nedoro uye zvimwe zvinowedzera, izvo zvinogona kuwedzera mutoro uye kukanganisa ma enzymes anobvisa histamine.
Yambiro yakakosha ndeyekuti kudya kwakaderera-histamine kunoganhurira, uye humbowo hwakaburitswa hunovatsigira hushoma uye hune mwero mhando. Kuwedzerwa kurambidzwa kusingatarisirwe kunotakura njodzi yechokwadi yekushaikwa kwekudya uye kudya zvisina tsarukano, uye njodzi yacho yakakura muvachiri kuyaruka.Vazhinji varapi vanokurudzira kuyedza nguva-yenguva, yakarongeka ine kudzoreredzwa kwakarongeka - uye kubatanidzwa kwechiremba wezvekudya apo mumwe anowanikwa - pane kuvhurika-kudzivisa kudzivirira.
Kushungurudzika, Mahomoni
& Urwere
Hazvisi zvese zvinokonzeresa zvinobva kunze. Mamwe ane simba kwazvo anomuka kubva kumuviri wega wemukati mamiriro - icho chiri chikamu chechikonzero nei MCAS ichigona kupisa panguva iyo pasina chekunze chachinja.
Stress chinhu chinokonzeresa chimiro chemuviri, kwete chirungamutauro. Mast cells anotakura mareceptor ecorticotropin-releasing hormone uye anogara padyo nemagumo etsinga, achipa tsinga dzetsinga nzira yakananga yekupesvedzera activation yavo. Iyi nzira inofanirwa kusimbiswa, nokuti varwere vane zviratidzo zvinowedzera pasi pekunetseka vanowanzoudzwa kuti mamiriro acho ndeepfungwa.Iko kufungidzira hakuna kunaka: nzira inoratidzwa neuroimmune haina kufanana nechiratidzo chiri kufungidzira.
Hormonal fluctuation inowanzotaurwa, kunyanya pakuenda kumwedzi, uye vamwe varwere vanotsanangura shanduko panguva yekuzvitakura kana perimenopause. Estrogen inokanganisa mast cell maitiro, inova imwe tsananguro yekuti sei MCAS ichionekwa kazhinji muvakadzi.
Utachiona zvakavimbika inomutsa baseline reactivity. Varwere vazhinji vanoona kuti hurwere hwehutachiona hwemazuva ese hunowedzera kukonzeresa kwavo kwemavhiki anotevera, uye kuti zvinhu zvakamboshivirirwa zvinova zvinotsamwisa panguva yekupora.
Mishonga & Maitiro
Mimwe mishonga inogona kumutsa mast cell activation zvakananga. Iyi ndiyo imwe yenzvimbo shoma uko kuita zvisizvo kunotakura njodzi yakakura, uye inofanirwa kubatwa nevako vekiriniki.
Mamwe makirasi emishonga anozivikanwa mune mast cell mabhuku seanogona activator. Opioid, mamwe asiri-steroidal anti-inflammatory drugs, radiocontrast media, zvinozorodza tsandanyama zvinoshandiswa mukutindivadza, uye vancomycin zvinoonekwa nguva dzose. Haasi murwere wese anoita kune chero cheizvi, uye vazhinji vanozvitora pasina dambudziko.
Zvisina kushanda zvine basa zvakare. Dhayi, mapreservatives, uye mafillers mukugadzira anogona kuva chinhu chinotsamwisa panzvimbo pemushonga unoshanda, ndosaka murwere angadaira kune mumwe mugadziri wemushonga uye kushivirira wemumwe.
Kuvhiya uye kutindivadza kwakakodzera kurongwa mberi. Varwere vane mast cell diagnostic vanowanzo rairwa kuti vazivise zvikwata zvekuvhiya uye zvekutindivadza zuva risati rasvika, kuitira kuti vamiririri vagone kusarudzwa nemamiriro ezvinhu mupfungwa uye kufanotariswa kutariswa. Iyi inhaurirano yekutanga kutanga, kwete pakubvumidzwa.
Finding Your Zvikonzero
Nekuti matrigger seti ari ega, nzira chete yakavimbika ndeyekurongeka kwekuchengeta rekodhi. A trigger diary is unglamorous uye inoshanda.
Nyora kupfuura zvokudya. Cherechedza nguva yezuva, tembiricha yakadzikama, chawakadya uye kuti chaive chitsva sei, kuita zvemuviri, kushushikana uye kurara, kuratidzwa hwema, mishonga inotorwa, uye - yevarwere vari kumwedzi - kutenderera chinzvimbo. Zvadaro nyora zviratidzo nenguva yavo uye kuomarara. Dambudziko rekunonoka-rekuita zvinoreva kuratidzwa izvo zvakakosha zvinogona kugara maawa akati wandei chiratidzo chisati chatanga.
Vhiki mbiri dzinenge dzave shoma mapatani asati anyorwa, uye kureba kuri nani. Tarisa kudzokorora pane zviitiko pane tsananguro yechiitiko chimwe chete. Chinangwa ifungidziro yaunogona kuyedza, kwete mutongo.
Hunza diary kumaaphoyintimenti. Ndechimwe chezvinhu zvinobatsira izvo murwere anogona kupa chiremba: kongiri, kureba, uye zvakananga kwauri nenzira isina runyorwa rwakaburitswa. Inobatsirawo kusiyanisa chinokonzeresa chechokwadi kubva kune tsaona, izvo zvakaoma kuita kubva mundangariro chete.