Menene MCAS?
Mast Cell Activation Syndrome cuta ce ta rigakafi hali maimakon rigakafi yawa. Kwayoyin suna kasancewa cikin lambobi na al'ada kuma suna kama da tsari na al'ada - abin da ya canza shine yadda suke harbi cikin sauri.
Mast Cell Activation Syndrome (MCAS) wani yanayi ne wanda ƙwayoyin mast - sel na rigakafi da ke zaune a kusan kowane nau'in nama na jiki - suna kunna rashin dacewa kuma akai-akai, suna sakin masu shiga tsakani na sinadarai da yawa kuma a wasu lokuta waɗanda ba su da amfani mai amfani. Sakamakon shine alamar maimaitawa, bayyanar cututtuka na episodic da ke shafar tsarin gabobin jiki biyu ko fiye a lokaci daya.
Ma'anar tana da mahimmanci saboda ta keɓance MCAS da yanayin da yake kama da shi. Babu wani mummunan tarin sel da za'a samu akan biopsy, babu wani alerji guda daya da zai iya ganowa akan gwajin fata, kuma akai-akai babu rashin daidaituwa ko kadan akan aikin dakin gwaje-gwaje na yau da kullun. Rashin lafiyar yana rayuwa ne a bakin kofa wanda sel masu kama da al'ada suka yanke shawarar amsawa.
A cikin MCAS matsalar ba guda nawa Kwayoyin mast da kuke da su. Yana da yadda suke harbi cikin sauki. Kowane nau'in yanayin yanayin - rashin tabbas, yaduwar tsarin multisystem, gwaji mai wahala - ya biyo baya daga wannan gaskiyar.
Me yasa kwayoyin mast ke wanzu kwata-kwata
Mabuɗin Maɓalli
An sanya su daidai - suna mai da hankali a kan iyakoki, cikin fata, rufin iska, bangon hanji, da nama da ke kewaye da tasoshin jini da jijiyoyi. Kuma an gina su don saurin: maimakon kera martanin su akan buƙata, suna riƙe da an riga an yi shi a cikin granules na ajiya, a shirye su saki cikin daƙiƙa na sigina.Wannan gine-gine shine abin da ke sa rashin lafiyan dauki da sauri, kuma shine kuma abin da ke sa kunnawar da ba ta dace ba yana da wahalar rayuwa tare.
Me yasa kwayoyin mast ke wanzu kwata-kwata
Kwayoyin mast ba kuskuren ƙira ba ne. Suna daga cikin tsofaffin abubuwan da ke cikin tsarin rigakafi na halitta, wanda ke samuwa a cikin wani nau'i a cikin mafi yawan kashin baya, kuma suna yin aikin da jiki ke bukata na gaske.Suna hawan martani na farko ga ƙwayoyin cuta, suna taimakawa wajen kawar da dafin bayan hargowa da cizo, suna shiga cikin warkar da raunuka da gyaran nama, suna ba da gudummawa ga ƙayyadaddun ƙayyadaddun magudanar jini, da kuma taimakawa wajen kula da kyallen da ke raba jiki da duniyar waje.
An sanya su daidai - suna mai da hankali a kan iyakoki, cikin fata, rufin iska, bangon hanji, da nama da ke kewaye da tasoshin jini da jijiyoyi. Kuma an gina su don saurin: maimakon kera martanin su akan buƙata, suna riƙe da an riga an yi shi a cikin granules na ajiya, a shirye su saki cikin daƙiƙa na sigina.Wannan gine-ginen shine abin da ke sa rashin lafiyan dauki cikin sauri, kuma shine kuma abin da ke sa kunnawa mara dacewa da wuyar zama tare da shi.
Yaya aikin kwayar mast na al'ada yayi kama
A cikin cikakkiyar amsawar rigakafi, ƙwayar mast ɗin ta gamu da wata barazana ta gaske - antigen, dafin, ko lalacewar nama - kuma yana raguwa daidai da shi. Tasoshin jini suna faɗaɗa kuma su zama masu jurewa, suna barin plasma da ƙwayoyin rigakafi a cikin nama. Ƙarshen jijiyoyi suna motsa jiki, suna haifar da ƙaiƙayi ko zafi wanda ke jawo hankali ga shafin. Ana ɗaukar wasu ƙwayoyin rigakafi. Da zarar an kawar da barazanar, mayar da martani ya warware.
Duk abin da ba shi da daɗi game da wannan tsari yana aiki. Kumburi yana ba da abubuwan rigakafi zuwa rukunin yanar gizon. Ƙunƙashi yana sa ka cire duk abin da ke haifar da lahani. Mucus yana kama tarko kuma yana fitar da abubuwan ban haushi. A cikin daidaitaccen amsa, rashin jin daɗi na ɗan lokaci ne kuma fa'idar gaske ce.
A cikin MCAS, injin ɗin iri ɗaya yana kunna ba tare da madaidaicin dalili ba. Kwayoyin mast suna yin wuta ba tare da bata lokaci ba, ko kuma don mayar da martani ga abubuwan motsa jiki waɗanda yakamata su zama abin ban mamaki - ɗaki mai dumi, ƙamshi a cikin hallway, abinci, tsaye, motsa jiki mai sauƙi, rana ta yau da kullun. Masu shiga tsakani da aka saki iri ɗaya ne da ake amfani da su wajen kariyar da ta dace, amma ana sake su a cikin mahallin da ba daidai ba kuma galibi akai-akai.
Saboda ƙwayoyin mast suna zaune a cikin nama a ko'ina cikin jiki, kuma saboda masu shiga tsakaninsu suna aiki a kan tasoshin jini, tsoka mai santsi, jijiyoyi, da sauran ƙwayoyin rigakafi, wani abu guda ɗaya zai iya haifar da zubar da jini, bugun zuciya, ciwon ciki, rashin numfashi, da hazo a lokaci guda.Ga likitan da ba ya tunanin ƙwayoyin mast, wannan haɗin zai iya zama kamar matsalolin da ba su da alaka da su suna zuwa lokaci ɗaya - wanda shine babban ɓangare na dalilin da yasa aka rasa yanayin.
Misali mai sauƙi
| MCAS ba mastocytosis ba ne | Wannan shine ɗayan mafi mahimmancin bambanci a cikin filin, kuma rikitar da su biyun yana haifar da rudani game da duk abin da ke ƙasa. | |
|---|---|---|
| Mastocytosis idan aka kwatanta da MCAS | Mastocytosis | MCAS |
| Babban rashin daidaituwa | Kwayoyin mast da yawa sun taru a cikin nama | Adadin al'ada na sel mast, kunnawa bai dace ba |
| Ƙididdiga ta salula | Girma - yaduwar clonal | Na al'ada |
| Baseline tryptase | Ввввввввввввввввввввввввввввввввв maye gurbin D816V a mafi yawan lokuta na tsarin manya | Yawancin lokaci na al'ada a asali |
| Halin binciken kwayoyin halitta | Matsalolin mast cell mara kyau yana nunawa | Babu maye gurbi guda ɗaya da aka kafa |
| Binciken biopsy | Matsalolin mast cell mara kyau yana nunawa | Babu tarawar sifa |
| Alamar fata | Maculopapular raunuka (urticaria pigmentosa) na kowa a wasu nau'i | Babu takamaiman raunin fatar jiki |
Yadda aka tabbatar
Maƙasudin shaidar wuce gona da iri
Allergy na al'ada shine amsawar IgE-matsakaici zuwa takamaiman abu mai iya ganewa. Ana iya sake sakewa - bayyanar iri ɗaya yana haifar da amsa iri ɗaya - kuma yawanci ana iya nunawa ta hanyar gwajin fata ko takamaiman gwajin jini na IgE. Rashin lafiyar gyada yana yin haka; haka ma cat dander allergy.
Dukansu yanayi na iya haifar da bayyanar cututtuka masu rikitarwa, saboda a cikin lokuta biyu masu shiga tsakani na mast cell suna kaiwa nama fiye da kima. Amma ana iya nuna mastocytosis ta hanyar gano kwayoyin halitta; MCAS ba zai iya ba, wanda shine ainihin dalilin da ya sa ganewar asali ya dogara ne akan tarin ma'auni maimakon gwajin tabbatarwa guda ɗaya.
Yawancin marasa lafiya sun isa MCAS daidai saboda Gwajin alerji ya dawo da tsabta yayin da alamun su ba a bayyane suke ba. Ƙungiyar alerji mara kyau ba shaida ba ce game da sa hannu a cikin mast cell; a cikin wannan yanayin yana kusa da tsammanin.
Halin MCAS akai-akai ba sa. Mutane da yawa ba su da matsakaicin IgE kwata-kwata, suna tasowa maimakon ta hanyar sauran masu karɓa a saman mast cell ko ta hanyar motsa jiki kai tsaye. Abubuwan da ke haifar da sau da yawa na jiki ne - zafi, sanyi, matsa lamba, aiki - maimakon sunadaran, kuma ba a ƙirƙira kwamitin rashin lafiyar don gano waɗannan.Ana iya jinkirin martani ta hanyar sa'o'i, yanke hanyar haɗin kai tsakanin fallasa da tasiri, kuma ƙofa na iya canzawa tare da bacci, damuwa, yanayin hormonal, ko rashin lafiya na baya-bayan nan, don haka bayyanar da aka jure sati ɗaya yana haifar da amsa na gaba.
Lu'u-lu'u na asibiti
- MCAS cuta ce ta kwayar mast ɗin da ba ta dace ba kunnawa, ba na lambobin mast cell ba.
- Kwayoyin mast sel na rigakafi ne masu amfani bisa doka da aka sanya su a shingen jiki kuma an gina su don amsawa cikin daƙiƙa.
- Takaitaccen sashe
- Mastocytosis ya ƙunshi yawan ƙwayoyin sel kuma ana iya nunawa kai tsaye; MCAS ba zai iya ba, wanda shine dalilin da ya sa ganewar asali ya hade.
- Kwayoyin mast sel na rigakafi ne masu amfani bisa doka da aka sanya su a shingen jiki kuma an gina su don amsawa cikin daƙiƙa.
Fahimta Kwayoyin Mast
Gwajin alerji mara kyau ya zama ruwan dare a cikin MCAS kuma baya kawar da shi.
Asalin da ci gaba
Kwayoyin mast suna farawa a cikin kasusuwa, suna fitowa daga CD34-positive heematopoietic progenitor sel - adadin da ke haifar da wasu kwayoyin jini. Ba kamar yawancin fararen jini ba, duk da haka, ba sa kammala ci gaban su a can. Zuriyar da ba su balaga ba suna shiga cikin jini, suna zagayawa a taƙaice, sannan su yi ƙaura zuwa nama, inda matuƙar ƙarshe ta faru.
Wannan balagagge ya dogara sosai akan siginar kwayar halitta (SCF) ta hanyar mai karɓar KIT akan saman mast cell. Wannan hanya ita ce tsakiya ga ilmin halitta na mast cell, kuma hanya ɗaya ce ta rushe ta Ввввввввввввввввввввввввввввввввв maye gurbin D816V da aka samu a mafi yawan lokuta manya na mastocytosis na tsarin. Yanayin nama na gida yana siffanta phenotype na ƙarshe, wanda shine dalilin da yasa ƙwayoyin mast a cikin hanji sun bambanta da ma'auni da waɗanda ke cikin fata.
Asalin da ci gaba
Rarraba ko'ina cikin jiki
Kwayoyin mast suna rarraba da dabaru maimakon iri ɗaya, suna mai da hankali kan inda jikin ya hadu da duniyar waje da kewayen sifofin da ke ɗauke da sigina da jini. Wannan rarraba yana bayyana yanayin tsarin MCAS da yawa kai tsaye fiye da kowace hujja guda.
| Rarraba ko'ina cikin jiki | Kwayoyin mast suna rarraba da dabaru maimakon iri ɗaya, suna mai da hankali kan inda jikin ya hadu da duniyar waje da kewayen sifofin da ke ɗauke da sigina da jini. Wannan rarraba yana bayyana yanayin tsarin MCAS da yawa kai tsaye fiye da kowace hujja guda. | Inda ƙwayoyin mast ke zama, da abin da ke samarwa lokacin da suka yi kuskure |
|---|---|---|
| Wuri | Matsayi a cikin lafiya | Alamun lokacin kunnawa bai dace ba |
| Fata da dermis | Kare shinge; mayar da martani ga cizo, tururuwa, da rauni | Flushing, itching, amya, dermographism, kumburi |
| Gastrointestinal fili | Kula da shingen shinge, ƙa'idar motsi, martani ga barazanar ciki | Craming, tashin zuciya, reflux, zawo, maƙarƙashiya, kumburi |
| Hanyoyin iska da sinuses | Tsaro na rufin numfashi | Cunkoso, rhinitis, matsananciyar makogwaro, shaƙa, tari |
| A kusa da tasoshin jini | Ƙa'idar sautin jirgin ruwa da permeability | Hawan jini yana jujjuyawa, tachycardia, flushing, presyncope |
| Brain da meninges | Gabatar da perivascular da a cikin meninges; siginar neuroimmune | Hazo mai hankali, ciwon kai, dizziness (har yanzu ana nazarin injiniyoyi) |
| Nama mai haɗi | Gyaran nama da gyarawa | Ciwon haɗin gwiwa da tsoka; yuwuwar dacewa ga haɗewar nama |
Bargon kashi
Wurin asalin zuriyarsu
Kwayoyin mast suna da dadewa ba saban ba. Inda neutrophil zai iya rayuwa kawai sa'o'i zuwa kwanaki, ƙwayoyin mast na nama na iya dawwama na makonni zuwa watanni, kuma shaidu sun nuna wasu suna rayuwa da yawa. Hakanan suna da ikon sake haɓakawa - bayan lalatawar, ƙwayar mast ɗin na iya sake gina shagunan sa kuma ya sake mayar da martani, maimakon mutuwa a cikin tsari.
Kula da shigar kwakwalwa a hankali. Kwayoyin mast suna da gaske a cikin meninges kuma a cikin matsayi na perivascular a cikin tsarin juyayi na tsakiya, kuma mast cell-jijiya hulɗar yanki ne mai bincike mai aiki. Koyaya, hanyoyin da ke haɗa mast cell kunnawa zuwa takamaiman alamun jijiya da fahimi har yanzu ana aiki da su, kuma da'awar injiniyoyi a wannan yanki sun zarce shaidar yanzu.
Zagayowar rayuwa
Kwayoyin mast suna da dadewa ba saban ba. Inda neutrophil zai iya rayuwa kawai sa'o'i zuwa kwanaki, ƙwayoyin mast na nama na iya dawwama na makonni zuwa watanni, kuma shaidu sun nuna wasu suna rayuwa da yawa. Hakanan suna da ikon sake haɓakawa - bayan lalatawar, ƙwayar mast ɗin na iya sake gina shagunan sa kuma ya sake mayar da martani, maimakon mutuwa a cikin tsari.
- FcεRI - mai karɓar IgE mai girma. Wannan ita ce hanyar rashin lafiyar na gargajiya: IgE ƙwayoyin rigakafi suna ɗaure mai karɓa, da haɗin kai ta hanyar allergen yana haifar da kunnawa.
- MRGPRX2 - mai karɓar mai karɓa yana daidaitawa IgE mai zaman kansa kunnawa ta wasu kwayoyi da peptides. Halayensa ya taimaka bayyana halayen da ke faruwa ba tare da nuna alamar IgE ba.
- Ввввввввввввввввввввввввввввввввв - mai karɓa don ƙwayar ƙwayar ƙwayar cuta; tsakiya ga rayuwar mast cell, maturation, da mazaunin nama.
- Masu karɓa (C3a, C5a) - ba da damar kunnawa ta hanyar haɗin gwiwa na rigakafi na asali.
- Kuɗi-kamar masu karɓa - gane alamu masu alaƙa da ƙwayoyin cuta, haɗa ƙwayoyin mast zuwa martanin kamuwa da cuta.
- KIT - mai karɓa don ƙwayar ƙwayar ƙwayar cuta; tsakiya ga rayuwar mast cell, maturation, da mazaunin nama.
- Adenosine, opioid, estrogen da sauran masu karɓa - ba da gudummawa ga bambance-bambancen bayanan fa'ida da ɗaiɗaikun abubuwan da aka gani a aikace.
Kasancewar hanyoyin kunnawa marasa IgE da yawa shine dalilin da yasa daidaitaccen gwajin rashin lafiyar yakan dawo daidai a MCAS. Waɗannan gwaje-gwajen an gina su ne don gano faɗakarwa mai tsaka-tsakin IgE - hanya ɗaya tsakanin da yawa waɗanda za su iya kashe mast cell.
Hoton mast cell mai lakabi: membrane cell wanda aka haɗe tare da masu karɓa mai suna (FcεRI, MRGPRX2, KIT, C3a/C5a, TLRs, CRH-R), ciki cike da granules, tare da cutaway yana nuna abun ciki na granule. Saitin sahabi yana nuna tantanin halitta kafin da bayan lalacewa.
- Kwayoyin mast sun samo asali ne daga magabatan CD34+ a cikin bargo amma balagagge a cikin nama, don haka adadin jini baya nuna su.
- Kasancewar hanyoyin kunnawa marasa IgE da yawa shine dalilin da yasa daidaitaccen gwajin rashin lafiyar yakan dawo daidai a MCAS. Waɗannan gwaje-gwajen an gina su ne don gano faɗakarwa mai tsaka-tsakin IgE - hanya ɗaya tsakanin da yawa waɗanda za su iya kashe mast cell.
- Suna mai da hankali kan shingen shinge da kewayen tasoshin jini da jijiyoyi, wanda shine dalilin da ya sa MCAS ya zama multisystem.
- Suna da tsayi kuma suna iya sake sakewa, don haka ana ci gaba da gudanar da aiki maimakon ɗan gajeren lokaci.
- KIT/SCF siginar yana tsakiyar ci gaban su - hanyar da aka rushe a yawancin mastocytosis na tsarin manya.
Abin da ke Faruwa Lokacin
Kunna Mast Cell
Yawancin nau'ikan masu karɓa da suka wuce IgE na iya kunna su, wanda shine dalilin da ya sa bangarorin alerji sukan rasa abubuwan haifar da MCAS.
Kunnawa jeri ne, kuma kowane mataki yana da suna. Biye shi yana sa nau'ikan rikice-rikice na alamun MCAS ya fi sauƙin fassara.
Wani abin ƙarfafawa yana kaiwa ga tantanin halitta - allergen, miyagun ƙwayoyi, zafi, matsa lamba, motsa jiki, hormone damuwa, kamuwa da cuta, ko babu abin da zai iya ganowa kwata-kwata.
Masu karɓan sararin samaniya suna shiga kuma an fara siginar siginar cikin salula. shigowar Calcium muhimmin mataki ne na farko.
Ma'ajiyar granules suna haɗuwa tare da membrane na tantanin halitta kuma suna fitar da abubuwan da aka riga aka yi a cikin nama da ke kewaye - cikin daƙiƙa.
Ana sakin masu shiga tsakani da aka riga aka kafa; sababbin masu shiga tsakani kamar su prostaglandins da leukotrienes suna biyo baya a cikin mintuna, kuma cytokines na tsawon sa'o'i.
Fasaloli biyu na wannan jeri sun bayyana yawancin abin da marasa lafiya ke fuskanta. Na farko, lokaci na gaggawa yana zana kan shagunan da aka riga aka yi, wanda shine dalilin da ya sa halayen zasu iya farawa a cikin dakika. Na biyu, masu shiga tsakani na baya-bayan an fara kunnawa, wanda shine dalilin da ya sa wasu alamun bayyanar suna zuwa da kyau bayan abin da ya haifar da kuma dalilin da yasa amsa zai iya samun jinkirin jinkiri na biyu bayan sa'o'i.
Kwayoyin mast suna sakin matsakanci a ciki igiyoyin ruwa, ba lokaci guda ba. Masu shiga tsakani da aka riga aka kirkira suna fitarwa cikin dakika; ana gina masu shiga tsakani a cikin mintuna; cytokines suna taruwa cikin sa'o'i. Lamarin kunnawa ɗaya na iya haifar da alamun a duk tsawon yini.
Masu shiga tsakani suna aiki akan tasoshin jini, santsin tsoka, jijiyoyi, da sauran ƙwayoyin rigakafi, suna haifar da tasiri a cikin tsarin gabobin da yawa.
Manyan masu shiga tsakani da abin da kowannensu yake yi
Kwayoyin mast suna da ikon fitar da adadi mai yawa na abubuwa. Waɗannan su ne mafi yawan tattaunawa a asibiti, kuma tare suna lissafin mafi yawan sanannun hoton alamar.
| Manyan masu shiga tsakani da abin da kowannensu yake yi | Kwayoyin mast suna da ikon fitar da adadi mai yawa na abubuwa. Waɗannan su ne mafi yawan tattaunawa a asibiti, kuma tare suna lissafin mafi yawan sanannun hoton alamar. | Manyan matsakanci na mast cell |
|---|---|---|
| Ввввввввввввввввввввввввввввввввв | Nau'in | Mafi yawan matsakanci. Yana dishe hanyoyin jini kuma yana ƙara haɓakar su, yana ƙarfafa ƙarshen jijiyoyi, yana ƙara fitar da acid na ciki. Yana haifar da flushing, itching, amya, low blood pressure, tachycardia, ciwon kai, da GI cramping. Ayyuka ta hanyar nau'ikan nau'ikan masu karɓa da yawa - H1 a cikin fata da hanyar iska, H2 a cikin gut da kan zuciya - wanda shine dalilin da yasa toshe duka azuzuwan sau da yawa yana aiki mafi kyau fiye da toshe ko dai. |
| Histamine | Nau'in | An riga an yi shi |
| Prostaglandin D2 | Sabbin hadawa | Mafi yawan furotin a cikin granules na mast cell da mafi girman alamar dakin gwaje-gwaje na kunnawa. Yana ba da gudummawa ga gyare-gyaren nama da kumburi, kuma yana iya haɓaka ƙarin martanin kwayar halitta. Ƙimar bincikenta ta fito ne daga kasancewa ta musamman ga ƙwayoyin mast. |
| Leukotrienes (LTC4, LTD4, LTE4) | Sabbin hadawa | M bronchoconstrictors, da yawa fiye da histamine ta nauyi. Ƙara haɓakar jijiyoyin jini da kuma samar da gamsai, kuma suna ba da gudummawa ga duka hanyoyin iska da alamun gastrointestinal. LTE4 ana iya aunawa a cikin fitsari. |
| Cytokines (IL-6, TNF-a, IL-1, IL-4 da sauransu) | Sabbin hadawa | Sunadaran siginar suna haifar da kumburi mai faɗi. Sannu a hankali a farawa da tsayin aiki fiye da masu shiga tsakani a sama, kuma ana tunanin taimakawa ga gajiya, rashin lafiya, da kuma tsarin 'mura-kamar' ingantattun majiyyata suna bayyana lokacin da bayan tashin. |
| Chemokines | Sabbin hadawa | Daukar ƙarin ƙwayoyin rigakafi zuwa rukunin yanar gizon, haɓakawa da tsawaita martanin kumburi fiye da matakin farko na mast cell. |
| Sakamakon kunnawa na platelet (PAF) | Sabbin hadawa | Matsakaicin matsakaitan lipid mai ƙarfi wanda ke ƙara haɓakar jijiyoyin jini kuma yana iya haifar da hauhawar jini mai tsanani. Yana da tasiri a cikin tsananin halayen anaphylactic kuma ba a toshe shi ta hanyar antihistamines. |
| Heparin | Nau'in | Maganin ciwon zuciya da ke faruwa a zahiri. Yana iya ba da gudummawa ga ƙwanƙwasa da ba a saba gani ba ko yanayin zub da jini da wasu marasa lafiya suka ruwaito, sannan kuma suna shiga cikin ƙa'idodin kumburin gida. |
| Chymase & carboxypeptidase A3 | Nau'in | Granule proteases yana shiga cikin gyaran gyare-gyaren nama, hanyoyin daidaita karfin jini, da lalata wasu dafin da peptides. |
Maganin ciwon zuciya da ke faruwa a zahiri. Yana iya ba da gudummawa ga ƙwanƙwasa da ba a saba gani ba ko yanayin zub da jini da wasu marasa lafiya suka ruwaito, sannan kuma suna shiga cikin ƙa'idodin kumburin gida.
Taswirar tsari mai gudana daga hagu zuwa dama: Trigger → Kunnawa → Ragewa → Sakin matsakanci → Alamomi, tare da tsarin lokaci na reshe a ƙasa yana nuna masu shiga tsakani da aka riga aka kafa a cikin daƙiƙa, masu shiga tsakani a cikin mintuna, da cytokines a cikin sa'o'i, kowane reshe yana ba da bayanin alamun da yake fitarwa.
- Granule proteases yana shiga cikin gyaran gyare-gyaren nama, hanyoyin daidaita karfin jini, da lalata wasu dafin da peptides.
- Masu shiga tsakani da aka riga aka kafa suna sakin cikin daƙiƙa; masu shiga tsakani na lipid a cikin mintuna; cytokines na tsawon sa'o'i.
- Kwayoyin mast na iya sakin masu shiga tsakani zaɓen ba tare da cikakkiyar lalacewa ba.
- Kunnawa yana biye da jeri: fararwa, kunnawa, lalata, sakin matsakanci, alamu.
- Masu shiga tsakani da aka riga aka kafa suna sakin cikin daƙiƙa; masu shiga tsakani na lipid a cikin mintuna; cytokines na tsawon sa'o'i.
Alamomin Ввввввввввввввввввввввввввввввввв
PAF da prostaglandins na iya haifar da mummunan tasirin cututtukan zuciya wanda antihistamines ba su magance ba.
Teburan da ke ƙasa suna tsara alamun bayyanar cututtuka da aka ruwaito ta tsarin jiki. Gargaɗi biyu kafin karanta su. Na farko, babu majiyyaci da ke da waɗannan duka, kuma bai kamata a karanta dogon jeri a matsayin jerin abubuwan da za su dace da su ba. Na biyu, kowace alama a nan tana faruwa a wasu yanayi da yawa; abin da ke nuna MCAS shine tsari - episodic, maimaitawa, multisystem, sau da yawa tare da abubuwan da za a iya gane su - maimakon kowane shigarwa.
| An siffanta MCAS da faɗin sa. Saboda ƙwayoyin mast suna zaune a kusan kowane nama, alamun cututtuka na iya bayyana kusan ko'ina - kuma abin da ake bukata don tsarin gabobin jiki biyu ko fiye shine tsakiyar ganewar asali. | Bayanan kula |
|---|---|
| Fata da mucosal | Alama |
| Bayanan kula | Fitowa |
| Sau da yawa kwatsam, yana shafar fuska, wuyansa, da kirji; fasalin da aka ruwaito akai-akai | Itching (priritus) |
| Zai iya faruwa tare da ko ba tare da bayyanar kurji ba | Urticaria |
| Tasowa, ƙaiƙayi welts; na iya zama mai wucewa da ƙaura | ilimin halin dan Adam |
| Welts tashe ta m shafa na fata - a gane jiki alamar | Angioedema |
| An siffanta MCAS da faɗin sa. Saboda ƙwayoyin mast suna zaune a kusan kowane nama, alamun cututtuka na iya bayyana kusan ko'ina - kuma abin da ake bukata don tsarin gabobin jiki biyu ko fiye shine tsakiyar ganewar asali. | Bayanan kula |
|---|---|
| Jinkirin warkar da rauni | Wasu marasa lafiya ne suka ruwaito; hanyoyin ba su cika kafa ba |
| Na numfashi | Ciwon hanci da rhinitis |
| Sau da yawa na yau da kullun kuma ba na zamani ba | Ƙunƙarar maƙogwaro |
| Yana buƙatar kima na gaggawa idan an ci gaba - yana iya sigina anaphylaxis | Haihuwa da ƙarancin numfashi |
| Leukotriene-kore bronchoconstriction ne sananne inji | Tari na yau da kullun |
| An siffanta MCAS da faɗin sa. Saboda ƙwayoyin mast suna zaune a kusan kowane nama, alamun cututtuka na iya bayyana kusan ko'ina - kuma abin da ake bukata don tsarin gabobin jiki biyu ko fiye shine tsakiyar ganewar asali. | Bayanan kula |
|---|---|
| Hankali ga ƙamshi da sinadarai na iska | Alamar haɗakarwa da aka fi ba da rahoto |
| Zuciyar zuciya | Tachycardia |
| Racing zuciya, sau da yawa ba tare da aiki ba | Rashin zaman lafiyar hawan jini |
| Zai iya yin lilo a kowane bangare yayin da ake yin abubuwa | Presyncope da syncope |
| Haske-kai ko suma, sau da yawa akan tsaye | Rashin jin daɗin ƙirji |
| An siffanta MCAS da faɗin sa. Saboda ƙwayoyin mast suna zaune a kusan kowane nama, alamun cututtuka na iya bayyana kusan ko'ina - kuma abin da ake bukata don tsarin gabobin jiki biyu ko fiye shine tsakiyar ganewar asali. | Bayanan kula |
|---|---|
| Anaphylaxis | Mai tsanani, sauri, mai yuwuwar barazanar rayuwa - duba sashin gaggawa |
| Gastrointestinal | Ciwon ciki da zafi |
| Daga cikin mafi yawan bayyanar cututtuka gabaɗaya | Tashin zuciya da amai |
| Zai iya bin abinci ko faruwa da kansa | Tasirin H2 na histamine akan acid na ciki sanannen mai ba da gudummawa ne |
| Motsi na iya bambanta tsakanin aukuwa da kuma kan lokaci | Yawanci yana haifar da ƙuntatawa na abinci - duba taka tsantsan a sashe na 9 |
| An siffanta MCAS da faɗin sa. Saboda ƙwayoyin mast suna zaune a kusan kowane nama, alamun cututtuka na iya bayyana kusan ko'ina - kuma abin da ake bukata don tsarin gabobin jiki biyu ko fiye shine tsakiyar ganewar asali. | Bayanan kula |
|---|---|
| Bloating da abinci reactivity | Wahala tare da maida hankali, tunowa, da gano kalmomi |
| Neurological da fahimi | Hazo mai hankali |
| Wahala tare da maida hankali, tunowa, da gano kalmomi | Ciwon kai da ciwon kai |
| Ana ba da rahoton ƙaura a mafi girma a cikin wannan yawan | Dizziness |
| Yawancin lokaci yana mamayewa tare da sifofin zuciya da jijiyoyin jini | Gajiya |
| Yawaita mai tsanani kuma daga cikin alamun da aka ruwaito sun fi naƙasa | Hannun hankali |
| An siffanta MCAS da faɗin sa. Saboda ƙwayoyin mast suna zaune a kusan kowane nama, alamun cututtuka na iya bayyana kusan ko'ina - kuma abin da ake bukata don tsarin gabobin jiki biyu ko fiye shine tsakiyar ganewar asali. | Bayanan kula |
|---|---|
| Hanyoyi na Neuropathic | Za a iya haɗuwa da yanayin kyallen jikin da aka tattauna a sashe na 7 |
| Musculoskeletal, genitourinary, da kuma tunani | Ciwon haɗin gwiwa da tsoka |
| Gaggawar mafitsara da mita | Ciwon kashi |
| Ƙimar garanti, musamman mastocytosis shine la'akari | Gaggawar mafitsara da mita |
| Interstitial-cystitis-kamar bayyanar cututtuka an ruwaito | Alamomin da suka bambanta da yanayin haila |
| An rubuta tasirin Hormonal akan ƙwayoyin mast | Damuwa-kamar al'amura |
Shigar 'kamar damuwa' ta cancanci kulawa ta bangarorin biyu. Sakin matsakanci na iya haifar da ainihin ilimin halittar jiki na harin firgita, kuma akai-akai ana kuskuren ganewar marasa lafiya a kan haka. A lokaci guda, damuwa da ɓacin rai suna haɗuwa da gaske tare da rashin lafiya na yau da kullun kuma sun cancanci kulawa da kansu. Gane ɗaya baya buƙatar korar ɗayan.
Canjin yanayi da rashin jin daɗi
Dukansu daga tasirin matsakanci da kuma daga rayuwa tare da rashin lafiya na yau da kullun, rashin fahimta mara kyau
- Rarraba yanki. Yawan mast cell da phenotype sun bambanta tsakanin kyallen takarda da tsakanin daidaikun mutane, don haka tsarin gabobin da abin ya shafa sun bambanta.
- Sakin matsakanci daban-daban. Kwayoyin mast na iya sakin zaɓaɓɓun masu shiga tsakani maimakon cikakken abin da ke ciki, kuma gaurayawan matsakanci daban-daban suna haifar da alamu daban-daban.
- Bayanan martaba. Masu karɓan da aka bayyana akan sifar mast ɗin mutum waɗanda abubuwan motsa jiki ke aiki azaman abubuwan da ke jawo su.
- Rarraba yanki. Yawan mast cell da phenotype sun bambanta tsakanin kyallen takarda da tsakanin daidaikun mutane, don haka tsarin gabobin da abin ya shafa sun bambanta.
- Sakin matsakanci daban-daban. Kwayoyin mast na iya sakin zaɓaɓɓun masu shiga tsakani maimakon cikakken abin da ke ciki, kuma gaurayawan matsakanci daban-daban suna haifar da alamu daban-daban.
- Bayanan martaba. Masu karɓan da aka bayyana akan sifar mast ɗin mutum waɗanda abubuwan motsa jiki ke aiki azaman abubuwan da ke jawo su.
Taswirar jiki ta alama: jita-jita na jiki tare da lakabin kira zuwa kowane yanki da abin ya shafa - fata, hanyoyin iska, zuciya, hanji, kwakwalwa, haɗin gwiwa, mafitsara - kowane mai faɗaɗa don nuna alamun da ke tattare da wannan tsarin. Juyawa na iya haskaka tsarin tsarin da aka ba majiyyaci ke fuskanta.
- Alamun sun hada da fata, numfashi, zuciya da jijiyoyin jini, GI, neurological, musculoskeletal, genitourinary, da wuraren tunani.
- Shiga tsarin gabobin jiki biyu ko fiye wani bangare ne na tsarin gano cutar.
- Babu wata alama ta mutum ɗaya da ta keɓance ga MCAS - tsarin al'ada, tsarin tsarin multisystem shine abin da ke da mahimmanci.
- Alamun sun hada da fata, numfashi, zuciya da jijiyoyin jini, GI, neurological, musculoskeletal, genitourinary, da wuraren tunani.
- Shiga tsarin gabobin jiki biyu ko fiye wani bangare ne na tsarin gano cutar.
Na kowa Masu tayar da hankali
Damuwa-kamar al'amura na iya zama matsakanci-kore; bai kamata a yi amfani da wannan don kawar da yanayin ba, ko kuma watsi da buƙatun lafiyar kwakwalwa na gaske.
Kunnawa shine tarawa. Filaye da yawa masu iya jure wa juna da suka zo kusa tare na iya haye kofa babu wanda zai ketare shi kaɗai. Wannan shine ra'ayi ɗaya mafi fa'ida don yin ma'anar da alama bazuwar halayen.
Abinci
Masu tayar da hankali ba sa yin aiki su kaɗai. Kwayoyin mast suna amsa nauyin tarawa, wanda shine dalilin da ya sa abinci iri ɗaya, ɗaki, ko aiki na iya zama mara lahani wata rana kuma ba za a iya jurewa a gaba ba.
Zafi
Abinci
Abubuwan da ke haifar da abinci a cikin MCAS gabaɗaya suna da alaƙa da abun ciki na histamine ko don kai tsaye ga haushin tantanin halitta maimakon rashin lafiyar abinci na gargajiya. Histamine yana tarawa a cikin abinci yayin da yake tsufa, yana da ƙarfi, ko kuma ana adana shi, wanda shine dalilin da yasa sabo yakan fi mahimmanci fiye da takamaiman kayan masarufi - ana iya jure wa kifi iri ɗaya a ranar siyan kuma ba bayan kwana uku ba.Tsofaffin cukuka, naman da aka warke da naman da aka sarrafa, abinci da aka haɗe, da ragowar abubuwan da aka yi amfani da su akai-akai. Ƙungiya ta biyu ta bayyana tana sa ƙwayoyin mast ɗin su saki nasu histamine. Bambance-bambancen mutum ɗaya yana da yawa, kuma lissafin da aka buga an fi ɗaukar su azaman hasashe don gwadawa maimakon dokoki.
An bayar da rahoton cewa, iska mai sanyi, ruwan sanyi, ruwan sanyi, da wuraren da aka sanyaya abinci, suna jawo wasu marasa lafiya. Musamman, sauri canji Tsakanin yanayin zafi galibi ana kwatanta shi da muni fiye da ko dai matsananciyar riko.
Daga cikin abubuwan da ke haifar da jiki akai-akai. Shawa mai zafi da wanka, saunas, yanayin zafi, dakuna masu dumi, da abubuwan sha masu zafi duk ana ambaton su. Zafi ba ya buƙatar wani abu don shiga cikin jiki, wanda shine ɓangare na dalilin da ya sa daidaitattun gwajin rashin lafiyar ba zai iya gano shi ba.
Sanyi
Damuwa
Motsa jiki
Ƙunƙarar jiki shine ainihin abin da ke haifar da marasa lafiya da yawa, kuma wanda ke da farashi na gaske, tun da yake aiki yana da amfani ga lafiya da yanayi. Ƙarfin ƙarfi da ƙimar haɓaka gabaɗaya yana da mahimmanci fiye da jimlar tsawon lokaci, wanda shine dalilin da ya sa a hankali a hankali, hanyoyin ƙanƙantar ƙarfi - da aiki mai jujjuyawa ko aikin tushen ruwa inda ba a jure tsayin daka ba - galibi ana sarrafa su.
Damuwa
Damuwa wani abu ne na motsa jiki, ba siffar magana ba. Kwayoyin mast suna ɗaukar masu karɓa don corticotropin-sakin hormone kuma suna zaune a kusa da ƙarshen jijiyoyi, suna samar da hanyar da aka rubuta ta hanyar tsarin jin tsoro yana rinjayar aikin su. Wannan batu ya cancanci girmamawa saboda marasa lafiya waɗanda alamun su ke tsananta tare da damuwa akai-akai ana gaya musu yanayin su saboda haka tunani ne.Hanyar neuroimmune mai nunawa ba daidai ba ce da alamar da ake tunanin.
Hormones
Yawancin marasa lafiya suna ba da rahoton alamu na cyclical, sau da yawa suna tabarbarewa a kusa da haila. Estrogen yana rinjayar halayen mast cell, wanda shine mai ba da gudummawa ga mafi girman adadin ganewar asali a cikin mata. Canje-canje a lokacin daukar ciki, bayan haihuwa, da perimenopause kuma an bayyana su, kuma sun bambanta sosai tsakanin mutane.
Cututtuka
Kamuwa da cuta yana haifar da reactivity na asali ga yawancin marasa lafiya. Ciwon ƙwayar cuta na yau da kullun yana ƙara faɗaɗa saiti na makonni bayan haka, don haka bayyanar da aka jure a baya ya zama abin tsokana yayin murmurewa. Wasu marasa lafiya suna kwanan ranar bayyanar alamun su zuwa rashin lafiya mai yaduwa, ko da yake kafa dalili a cikin mutum ɗaya yana da wahala.
Bayyanar muhalli
Magunguna
Ana gane wasu nau'o'in magani a cikin wallafe-wallafen mast cell a matsayin masu kunnawa, ciki har da opioids, wasu magungunan anti-inflammatory marasa steroidal, kafofin watsa labaru na rediyo, wasu magungunan neuromuscular da ake amfani da su a cikin maganin sa barci, da vancomycin. Abubuwan da ba su da aiki - rini, abubuwan adanawa, filaye - suma suna iya zama bangaren tsokana, wanda shine dalilin da ya sa majiyyaci na iya jure ƙirar masana'anta kuma ya amsa ga na wani.
Muhimmanci
Kar a tsaya, gujewa, ko musanya magani da aka wajabta akan jeri na gaba ɗaya. Kawo lissafin ga likitan da ya san tarihin ku. Haɗarin dakatar da magani da ake buƙata zai iya wuce haɗarin da ake gujewa, kuma wannan yanke shawara yana buƙatar tantance mutum ɗaya.
Kamshi da kamshi
Turare, injin fresheners na iska, kayan tsaftacewa, kayan wanki, abubuwan kaushi, sabon fenti, da sabbin kayan daki suna daga cikin abubuwan da aka fi bayar da rahoto akai-akai, kuma daga cikin mafi wahalar gujewa a wuraren da aka raba. Wurin da ba shi da ƙamshi daidaitaccen buƙatun masauki a makarantu da wuraren aiki saboda wannan dalili.
Barasa
Ana ba da rahoton barasa akai-akai azaman mai jawo ta hanya fiye da ɗaya: yawancin abubuwan sha na giya suna ɗauke da histamine kai tsaye, musamman giya da giya; barasa na iya tsoma baki tare da enzymes da ke karya histamine; kuma yana haifar da vasodilation da kansa. Ana bayyana martani ga ƙananan adadi.
Saitunan tayar da hankali sun bambanta tsakanin daidaikun mutane saboda bayanan bayanan mai karɓa, rarrabawar nama, yanayin da suke tare, da sake kunnawa na asali duk sun bambanta. Suna kuma canza ciki mutum na tsawon lokaci - yawanci yana faɗaɗa yayin lokutan rashin kulawa da raguwa kuma sau ɗaya jiyya yana rage tasirin aiki. Ana iya jinkirta martani ta hanyar sa'o'i, wanda ke rufe hanyar haɗi tsakanin sanadi da sakamako. Saboda duk waɗannan dalilai, gano abubuwan da ke haifar da dogaro da gaske yana buƙatar rikodi na tsari sama da makonni maimakon yanke shawara daga al'amura guda ɗaya.
Talakawa ko rashin isasshen barci yana rage haƙuri gabaɗaya kuma yana hulɗa tare da kowane abu akan wannan jeri. Ba kasafai ne kadai ke haifar da tashin gobara ba, amma yana daya daga cikin masu bayar da gudummuwar da za a iya aiwatarwa, kuma marasa lafiya akai-akai suna bayar da rahoton cewa kare barci yana daga kofa ga komai.
- Me ya sa abubuwan jan hankali suka bambanta sosai
- Abubuwan da ke haifar da jiki (zafi, sanyi, matsa lamba, motsa jiki) ba sa buƙatar wani abu da aka ci kuma ba a ganuwa ga gwajin alerji.
- Danniya yana aiki ta hanyar da aka rubuta ta hanyar neuroimmune; wannan baya sanya yanayin tunani.
- Matsakaicin tari - tarin kaya yana da mahimmanci fiye da kowane fallasa guda ɗaya.
- Abubuwan da ke haifar da jiki (zafi, sanyi, matsa lamba, motsa jiki) ba sa buƙatar wani abu da aka ci kuma ba a ganuwa ga gwajin alerji.
Me yasa MCAS yake
Wahalar zuwa Bincike
Saitin tayar da hankali ya bambanta tsakanin mutane da canzawa akan lokaci, don haka kiyaye rikodin sirri yana da mahimmanci.
Alamomi masu canzawa
MCAS yana haifar da haɗuwa daban-daban a cikin marasa lafiya daban-daban, da haɗuwa daban-daban a cikin majiyyaci ɗaya na tsawon lokaci. Babu gabatarwa guda ɗaya da aka yi daidai da tsarin. Saboda alamomin daban-daban ba takamaiman ba ne, kowanne ana iya danganta su a fili ga yanayin gama gari idan aka yi la'akari da shi a keɓe.
Jinkirin ganowa a cikin MCAS ba shine farkon gazawar likitocin ɗaiɗaikun ɗaya ba. Ya biyo baya daga ƙayyadaddun abubuwan da za a iya gane yanayin yanayin da gwaje-gwajen da aka yi amfani da su don bincikar shi.
Alamomi masu canzawa
Sakin matsakanci na ɗan lokaci
Wannan ita ce babbar matsalar fasaha. Masu shiga tsakani da aka auna suna da gajerun rabin rayuwa. Serum tryptase yana kaiwa kololuwa a cikin 'yan sa'o'i kadan bayan amsawa sannan ya fadi; Ƙwararrun ƙwayoyin fitsari sun daɗe amma har yanzu suna nuna iyakacin taga. Samfurori tsakanin sassa na iya samun wani abu mai girma - ba saboda kunnawa ba ya faru, amma saboda ba za a iya auna shi ba.
Aikin jini na yau da kullun ba shi da ban mamaki a cikin MCAS. Cikakkun adadin jini, alamomin kumburi, da daidaitattun kwayoyin halitta yawanci na al'ada ne, kamar yadda alerji suke. Ana buƙatar gwaji na musamman na matsakanci, har ma wanda akai-akai yana dawo da sakamako na yau da kullun saboda dalilai na fasaha da aka rufe a ƙasa.Don haka majiyyaci na iya tara babban fayil na bincike na al'ada yayin da yake rashin lafiya da gaske - yanayin da abin takaici yana ƙara yuwuwar a gaya masa cewa babu abin da ba daidai ba.
Babban rabo na sakamakon matsakanci mara kyau yana nunawa lokaci da handling maimakon rashin cuta. Tabbatar da ƙa'idar tattarawa tare da likitan da ke ba da oda da kuma dakin gwaje-gwaje kafin yin samfur yana da daraja fiye da maimaita gwaji mara kyau.
Matsawa tare da wasu cututtuka
Abubuwan da ake buƙata suna haɓaka wannan. Masu shiga tsakani da yawa ba su da kwanciyar hankali a cikin ɗaki, kuma samfuran prostaglandin suna da rauni musamman. Samfuran yawanci suna buƙatar sanyin gaggawa, kulawa da sanyi a duk lokacin tarin, da sarrafa gaggawa. Samfurin da aka bari a zafin daki ko jinkirin tafiya zai iya samar da sakamako na yau da kullun daga majiyyaci wanda ke amsawa da gaske.
Rashin sanin likita
An kwatanta MCAS bisa ƙa'ida ne kawai a cikin 2007, tare da ƙa'idodin yarjejeniya da ke biyo baya a cikin 2010 da 2012. Yawancin likitocin da ke aiki sun kammala horar da su kafin yanayin ya shiga tsarin koyarwa na yau da kullun. Sanin ya bambanta ko'ina har ma tsakanin masu fama da rashin lafiyar jiki da rigakafi, kuma samun damar yin amfani da ƙwararrun ƙwararrun ƙwayoyin ƙwayar cuta ba daidai ba ne a yanayin ƙasa.
Alamun MCAS sun mamaye sosai tare da ciwon hanji mai ban haushi, urticaria na yau da kullun, asma, fibromyalgia, ciwo na gajiya, rashin damuwa, dysautonomia, da wasu da yawa. Kowannen waɗannan ya fi sanin yawancin likitocin kuma an fi gano su. Lokacin da majiyyaci ya gabatar da alamun da suka dace da da yawa daga cikin waɗannan ɓangarorin, sakamakon da aka saba shine jerin ɓangarori na ɓangarori maimakon haɗin kai.
Rashin sanin likita
Wannan ba rashin jituwa ba ne da aka haifar da marasa lafiya, kuma ba a warware shi ba. Sakamakonsa na zahiri shine ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun biyu na iya cimma matsaya daban-daban game da majiyyaci ɗaya. Fahimtar cewa rigimar ta wanzu yana taimakawa wajen bayyana ra'ayoyi masu karo da juna ba tare da buƙatar zato cewa likitan likitancin ya yi kuskure ba.
Rigimar bincike
Yana da kyau a fayyace a sarari cewa ƙa'idodin bincike na MCAS ya kasance batun muhawara na gaske a cikin littattafan likitanci. Gabaɗaya, matsayi ɗaya yana riƙe da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun shaida na matsakanci na haƙiƙa, bisa dalilin cewa idan ba tare da shi ba, haɗarin ganewar asali ana amfani da shi sosai.Wani matsayi yana riƙe da ƙaƙƙarfan ma'auni sun rasa marasa lafiya waɗanda ke da yanayin gaske amma waɗanda gwajin matsakanci ya yi ta kasa akai-akai saboda dalilan fasaha da aka kwatanta a sama.
Wannan ba rashin jituwa ba ne da aka haifar da marasa lafiya, kuma ba a warware shi ba. Sakamakonsa na zahiri shine ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun biyu na iya cimma matsaya daban-daban game da majiyyaci ɗaya. Fahimtar cewa rigimar ta wanzu yana taimakawa wajen bayyana ra'ayoyi masu karo da juna ba tare da buƙatar zato cewa likitan likitancin ya yi kuskure ba.
- Jinkirin bincike
- Masu shiga tsakani ba su da ɗan gajeren lokaci kuma ba su da kwanciyar hankali, don haka lokaci da sarrafa samfurin suna haifar da ɓarna da yawa.
- Alamun sun zo tare da wasu sanannun yanayi, suna haifar da bincike-bincike.
- Gwajin gwaje-gwaje na yau da kullun na al'ada ne a cikin MCAS; Ana buƙatar gwajin matsakanci na musamman.
- Masu shiga tsakani ba su da ɗan gajeren lokaci kuma ba su da kwanciyar hankali, don haka lokaci da sarrafa samfurin suna haifar da ɓarna da yawa.
Mai alaƙa Sharuɗɗa
Sharuɗɗan bincike suna ci gaba da hamayya da gaske, don haka ra'ayoyin ƙwararrun na iya bambanta bisa doka.
Ƙungiya ba dalili ba ne. Sharuɗɗa da yawa da ke ƙasa suna faruwa tare da MCAS sau da yawa fiye da kwatsam da za a iya hangowa, amma ko sun raba hanya, ko ɗayan yana haifar da wani, ko kuma hanyoyin da aka raba suna haifar da ruɓani. ba a kafa ba don yawancin waɗannan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan iri ne.
Postural Orthostatic Tachycardia Syndrome (tukunya)
Karanta wannan tukuna
Hypermobile Ehlers-Danlos Syndrome (hEDS) da rikice-rikice na bakan motsi
Haɗin gwiwar hEDS, POTS, da MCAS ana tattaunawa akai-akai don a siffanta su ba bisa ƙa'ida ba azaman triad. Ana ba da rahoton ƙungiyar akai-akai, amma tsarin da ke ƙasa ya kasance a cikin hasashe. Kwayoyin mast suna zaune a cikin nama mai haɗawa kuma suna shiga cikin gyaran nama, wanda ke ba da layin bincike mai ma'ana, amma tabbas ba shaida ba. Alamar magana da tsarin bincike na iya ba da gudummawa ga yadda ƙarfi ya bayyana.
Halin alpha tryptasemia (HaT)
HaT wata dabi'a ce ta kwayoyin halitta wacce ta kunshi karin kwafi na kwayar halittar alpha-tryptase TPSAB1, wanda aka gada a cikin tsari mai mahimmanci na autosomal, kuma yana haifar da haɓakar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta tryptase. Kwatankwacin na kowa a cikin jama'a gabaɗaya. Har yanzu ana fayyace dangantakarta da alamomi: yana da alaƙa da halayen da suka fi tsanani a wasu mahallin, amma mutane da yawa waɗanda ke da yanayin suna asymptomatic.
HaT yana da mahimmanci a zahiri don fassara. Saboda yana ɗaga tushen tryptase, ƙimar tryptase guda ɗaya a cikin mutumin da ke da HaT ba ta nuna kanta da kunna mast cell ba - wanda ke ƙarfafa dalilin da yasa aka bayyana ma'anar tantancewar a matsayin: tashi sama da tushen tushen mutum maimakon cikakken lamba.
Halin alpha tryptasemia (HaT)
Alamun gastrointestinal a cikin MCAS sun mamaye kusan gaba ɗaya tare da ma'aunin IBS, kuma wasu marasa lafiya suna ɗauke da alamun biyu. Bincike ya bincika ƙwayar mast cell da kunnawa a cikin mucosa na gut na marasa lafiya na IBS tare da bincike daban-daban. Ko wani yanki na IBS yana wakiltar sa hannun mast cell wanda ba a gane shi ba buɗaɗɗen tambaya ne maimakon tabbataccen gaskiya.
Migraine
An ba da rahoton Migraine a matsayi mai girma a tsakanin marasa lafiya na MCAS. Histamine wani abu ne wanda aka kafa vasoactive tare da sanin mahimmancin ciwon kai, kuma ƙwayoyin mast suna nan a cikin meninges. Haɗin injin injin yana da inganci ta ilimin halitta kuma ana kan bincike, amma ba a daidaita ba.
Asthma da na kullum urticaria
Migraine
An ba da rahoton Migraine a matsayi mai girma a tsakanin marasa lafiya na MCAS. Histamine wani abu ne wanda aka kafa vasoactive tare da sanin mahimmancin ciwon kai, kuma ƙwayoyin mast suna nan a cikin meninges. Haɗin injin injin yana da inganci ta ilimin halitta kuma ana kan bincike, amma ba a daidaita ba.
Wasu masu bincike sun ba da shawarar kunna mast cell a matsayin mai ba da gudummawa ga Dogon COVID, tare da lura da alamun haɗuwa a cikin gajiya, wahalar fahimta, da dysautonomia. Wannan yanki ne na bincike mai aiki kuma shaida ita ce na farko. Ya kamata a kula da shi azaman hasashe a ƙarƙashin binciken maimakon ƙaƙƙarfan dangantaka, da iƙirarin haɗin kai - ta kowace hanya - a halin yanzu ya wuce bayanan.
Waɗannan suna da mafi bayyananniyar alaƙar injina zuwa mast cells na kowane abu a wannan sashe. Kwayoyin mast sune tsakiya ga pathophysiology na duka biyu - leukotrienes da histamine drive bronchoconstriction da whal samuwar bi da bi. Urticaria na lokaci-lokaci musamman ya ƙunshi kunna mast cell kai tsaye.Waɗannan ba ƙungiyoyin hasashe ba ne; yanayi ne wanda aka kafa shigar mast cell, ko da yake sun kasance daban-daban masu bincike daga MCAS.
Dogon COVID
| Yanayin rashin lafiya | Yanayin dangantakar | Ƙarfin shaida a kallo |
|---|---|---|
| Sharadi | Yanayin dangantakar | Matsayin shaida |
| Urticaria na yau da kullun | Kunna mast cell shine tsakiyar cutar kanta | Matsayin shaida |
| Tsarin tsari | Asma | Masu shiga tsakani na mast cell suna motsa bronchoconstriction |
| Halin alpha tryptasemia | Halin Halittar Halittar Halittar Halittar Halittar Jiki; yana rinjayar fassarar gwaji | Siffar da aka kafa; Alamar alamar har yanzu ana bayyanawa |
| Tukwane | Yawan faruwa tare; tasirin matsakanci akan sautin jijiyoyin jini da aka gabatar | Kungiyar ta ruwaito; inji ba a warware |
| Migraine | hEDS / hypermobility | Yawan faruwa tare; haɗewar nama da aka yi niyya |
| Kungiyar ta ruwaito; inji hasashe | An bayar da rahotanni masu girma; masu shiga tsakani na vasoactive m | Kungiyar ta ruwaito; tsarin da ake nazari |
| IBS | Alamun zoba; Matsalolin gut mast cell m | Matsawa bayyane; dangantaka ba a warware |
| An ba da rahoton Migraine a matsayi mai girma a tsakanin marasa lafiya na MCAS. Histamine wani abu ne wanda aka kafa vasoactive tare da sanin mahimmancin ciwon kai, kuma ƙwayoyin mast suna nan a cikin meninges. Haɗin injin injin yana da inganci ta ilimin halitta kuma ana kan bincike, amma ba a daidaita ba. | Cutar cututtuka | An bayar da rahoton cewa; raba rigakafi dysregulation shawara |
- An kafa shigar mast cell a cikin urticaria na yau da kullun da kuma asma - waɗannan ba haɗin kai ba ne.
- Alamun zoba; Hasashen mast cell hasashe
- Na farko - ƙarƙashin bincike mai aiki
- An kafa shigar mast cell a cikin urticaria na yau da kullun da kuma asma - waɗannan ba haɗin kai ba ne.
- HaT shine ainihin dabi'ar kwayoyin halitta wanda ke tayar da tryptase na asali kuma ya canza yadda dole ne a karanta sakamakon gwaji.
Fahimtar Yanzu
na Dalilai
A cikin wannan yanki, an yi kuskuren ƙungiyar akai-akai don haddasawa - karanta da'awar a hankali.
Ba a kafa dalili ɗaya na MCAS ba. Abubuwan da ke ƙasa sune wuraren bincike tare da matakan tallafi daban-daban. Duk wata hanyar da ke gabatar da tabbaci, haɗin kai na dalilin MCAS a halin yanzu ya wuce shaidar.
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Abin da aka kafa: Halin alpha tryptasemia na gada na gaske ne, siffa ce ta dabi'ar halitta wacce ta ƙunshi ƙarin kwafin TPSAB1, kuma yana tayar da tryptase na asali. Na dabam, da Ввввввввввввввввввввввввввввввввв An kafa maye gurbin D816V a matsayin direba a yawancin mastocytosis na tsarin manya - yanayi daban-daban, amma wanda ke nuna yadda maye gurbin guda ɗaya zai iya lalata ilimin halitta na mast cell.
Abin da ba: Ba a gano madaidaicin maye gurbi na MCAS ba. An ba da rahoton tarin iyali, kuma wasu marasa lafiya sun bayyana dangi da yawa da abin ya shafa, amma ba a kafa ƙayyadadden tsarin gado ga MCAS kanta ba. Ko MCAS yana wakiltar yanayi ɗaya tare da tushen kwayoyin halitta har yanzu ba a samo shi ba, ko wasu yanayi daban-daban da aka haɗa su ƙarƙashin lakabin asibiti ɗaya, ba a warware ba.
Genetics
Faɗaɗɗen ƙayyadaddun ƙayyadaddun ƙayyadaddun rigakafi shine babban yanki na bincike. Hanyoyin da aka tsara sun haɗa da sauya magana mai karɓa ko hankali akan ƙwayoyin mast, rushewar siginar tsari wanda yawanci zai hana kunnawa, da mu'amala mara kyau tsakanin ƙwayoyin mast da sauran yawan rigakafi. Waɗannan a bayyane suke kuma an yi nazari sosai, amma sun bayyana wani nau'in bayani maimakon tsari da aka nuna.
Damuwa wani abu ne na motsa jiki, ba siffar magana ba. Kwayoyin mast suna ɗaukar masu karɓa don corticotropin-sakin hormone kuma suna zaune a kusa da ƙarshen jijiyoyi, suna samar da hanyar da aka rubuta ta hanyar tsarin jin tsoro yana rinjayar aikin su. Wannan batu ya cancanci girmamawa saboda marasa lafiya waɗanda alamun su ke tsananta tare da damuwa akai-akai ana gaya musu yanayin su saboda haka tunani ne.Hanyar neuroimmune mai nunawa ba daidai ba ce da alamar da ake tunanin.
Yawancin marasa lafiya suna yin kwanan wata alamar bayyanar cututtuka na kamuwa da cuta. An san kamuwa da cuta don kunna ƙwayoyin mast ta hanyar masu karɓa kamar Toll, suna ba da hanya mai ma'ana, kuma farkon kamuwa da cuta sanannen tsari ne a cikin yanayi na yau da kullun. Koyaya, tabbatar da cewa kamuwa da cuta ya haifar MCAS a cikin yanayin mutum ɗaya yana da wahala sosai a tsarin tunani, kuma tunawa da son zuciya yana shafar asusun da ake bi. Wannan ya kasance ƙungiyar da ake nazari.
dysregulation na rigakafi
Faɗaɗɗen ƙayyadaddun ƙayyadaddun ƙayyadaddun rigakafi shine babban yanki na bincike. Hanyoyin da aka tsara sun haɗa da sauya magana mai karɓa ko hankali akan ƙwayoyin mast, rushewar siginar tsari wanda yawanci zai hana kunnawa, da mu'amala mara kyau tsakanin ƙwayoyin mast da sauran yawan rigakafi. Waɗannan a bayyane suke kuma an yi nazari sosai, amma sun bayyana wani nau'in bayani maimakon tsari da aka nuna.
Kumburi na yau da kullun
Abubuwan muhalli
Masu ba da gudummawar muhalli da aka tsara sun haɗa da fallasa sinadarai, mold, gurɓataccen iska, da canje-canjen abinci a matakin yawan jama'a. Shaida a nan ta yi rauni sosai fiye da wuraren da ke sama, kuma yawancin ta kai tsaye. Wannan yanki ne mai ma'ana na bincike maimakon kafaffen mai ba da gudummawa, kuma kuma yanki ne da da'awar kasuwanci ta zama gama gari kuma ba ta da tallafi.
Kumburi na yau da kullun
Kwayoyin Mast duka suna amsawa kuma suna ba da gudummawa ga kumburi, wanda ke haifar da yiwuwar sake zagayowar motsa jiki wanda kunnawa ya haifar da yanayin kumburi wanda ya rage kofa don ƙarin kunnawa. Wannan yana da daidaituwa ta injina kuma ya yi daidai da lurawar asibiti wanda ke haɓaka haɓakawa yayin rashin kulawa. Ya kasance abin koyi maimakon dalili da aka nuna.
Epigenetics
Shaida-shaida zane: concentric makada motsi waje daga 'Established' (HaT hali; KIT D816V a mastocytosis) ta hanyar 'Bincike sosai tare da goyan bayan shaida' (na rigakafi da tsarin, bayan kamuwa da cuta farkon) zuwa 'Hypothesised, iyakance kai tsaye shaida' (epigenetics, fili bayyananne).
- Inda wannan ya bar abubuwa
- HaT da KIT D816V maye gurbi a cikin mastocytosis an kafa su ne kwayoyin halitta - kuma ba tabbataccen dalilin MCAS ba ne.
- Ana bincikar dysregulation na rigakafi da kuma farkon kamuwa da cuta tare da wasu shaidun tallafi.
- Gudunmawar muhalli da ta epigenetic hasashe ne tare da iyakataccen shaida kai tsaye.
- Bi da da'awar 'tushen dalili' tare da shakka - ƙungiyar bincike ba ta gano ɗaya ba.
Rayuwa Da Ввввввввввввввввввввввввввввввввв
Bi da da'awar 'tushen dalili' tare da shakka - ƙungiyar bincike ba ta gano ɗaya ba.
Gudanar da yau da kullun da abubuwan yau da kullun
Yawancin marasa lafiya suna gano cewa daidaito yana ɗaga ƙofa fiye da kowane ma'auni. Lokacin bacci na yau da kullun da lokacin farkawa, lokacin cin abinci da ake iya tsinkaya, kwanciyar hankali na yanayi inda za'a iya cimmawa, da daidaiton lokacin magani duk suna rage sauye-sauye. Ayyukan na yau da kullun kuma suna sa gano abin da zai iya yiwuwa: lokacin da yawancin masu canji suka tsaya tsayin daka, waɗanda suka canza sun zama bayyane.
An gina gudanarwa da yawa daga ayyukan yau da kullun maimakon daga kowane sa baki ɗaya. Abin da ke biyo baya yana karkata zuwa aiki - manufar ita ce mafi girman rayuwar da ilimin halittar ku zai tallafawa.
Gudanar da yau da kullun da abubuwan yau da kullun
Yawancin marasa lafiya suna gano cewa daidaito yana ɗaga ƙofa fiye da kowane ma'auni. Lokacin bacci na yau da kullun da lokacin farkawa, lokacin cin abinci da ake iya tsinkaya, kwanciyar hankali na yanayi inda za'a iya cimmawa, da daidaiton lokacin magani duk suna rage sauye-sauye. Ayyukan yau da kullun kuma suna ba da damar ganowa: lokacin da yawancin masu canji suka tsaya tsayin daka, waɗanda suka canza suna bayyana.
Pacing jigo ne mai maimaitawa a cikin asusun masu haƙuri - rarraba ayyuka a cikin yini ɗaya ko mako maimakon mayar da hankali kan shi, da ginawa cikin lokacin dawowa bayan sanannun buƙatun. Wannan ba daidai yake da rashin aiki ba, kuma rashin aiki na tsawon lokaci yana ɗaukar nasa ingantaccen ƙididdiga na farashi.
Littafin bayanin kula yana ɗaya daga cikin mafi fa'ida abubuwan da majiyyaci zai iya kawowa ga alƙawari: kankare, madaidaiciya, da takamaiman su ta hanyar da ba za a iya buga jerin abubuwan faɗakarwa ba. Hakanan yana taimakawa bambance ainihin abubuwan jan hankali daga daidaituwa, wanda ƙwaƙwalwar ajiya kaɗai ke yin mara kyau.
Rubuce-rubucen da aka tsara ita ce hanya mafi aminci don gano abubuwan da ke jawo mutum. Abubuwan shigarwa masu amfani sun wuce abinci: lokacin rana, zafin jiki na yanayi, abin da aka ci da kuma yadda yake sabo, aikin jiki, damuwa da barci, bayyanar ƙanshi, magungunan da aka dauka, da - ga marasa lafiya na haila - matsayi na sake zagayowar. Ya kamata a rubuta alamun tare da lokaci da tsanani.
Gabatar da alamun da aka tsara ta tsarin gabobin jiki maimakon tsarin lokaci da lokaci ya sa tsarin tsarin multisystem ya bayyana nan da nan, inda asusun ba da labari ke ƙoƙarin ɓoye shi. Samar da sakamakon farko - gami da na yau da kullun - yana da cikakken bayani kuma yana guje wa maimaita binciken da aka kammala.
Littafin bayanin kula yana ɗaya daga cikin mafi fa'ida abubuwan da majiyyaci zai iya kawowa ga alƙawari: kankare, madaidaiciya, da takamaiman su ta hanyar da ba za a iya buga jerin abubuwan faɗakarwa ba. Hakanan yana taimakawa bambance ainihin abubuwan jan hankali daga daidaituwa, wanda ƙwaƙwalwar ajiya kaɗai ke yin mara kyau.
Yin aiki tare da likitoci
Wuraren masauki na gama gari sun haɗa da manufofin aji marasa ƙamshi, izinin ɗaukar magani da sarrafa kansa, samun ruwa da hutu, la'akari da yanayin zafi a wurin zama, sassauƙa a kusa da halarta yayin walƙiya, da daidaitawa don ilimin motsa jiki. Inda tsare-tsaren masauki na yau da kullun suka kasance a cikin tsarin ilimin ku, samun rubuce-rubucen ganewar asali a rubuce gabaɗaya yana ba da damar samun su da sauƙi.
Tambaya kai tsaye game da lokacin gwajin matsakanci da sarrafa samfurin yana da ma'ana kuma ta zahiri yana haɓaka damar sakamako mai amfani. Idan ba a saurare ku ba, neman ra'ayi na biyu halal ne; Cutar sankarau wuri ne mai kyau kuma sananne ya bambanta sosai. Yin sallama sau ɗaya abu ne na kowa kuma ba hukunci ba ne.
Makaranta
Wuraren masauki na gama gari sun haɗa da manufofin aji marasa ƙamshi, izinin ɗaukar magani da sarrafa kansa, samun ruwa da hutu, la'akari da yanayin zafi a wurin zama, sassauƙa a kusa da halarta yayin walƙiya, da daidaitawa don ilimin motsa jiki. Inda tsare-tsaren masauki na yau da kullun suka kasance a cikin tsarin ilimin ku, samun rubuce-rubucen ganewar asali a rubuce gabaɗaya yana ba da damar samun su da sauƙi.
Aiki
Abubuwan da ake la'akari da wuraren aiki suna kwatanta waɗancan na makaranta: manufofin ƙamshi, sarrafa zafin jiki, sassauƙaƙa ko shirye-shirye masu nisa yayin walƙiya, da gyare-gyaren jadawalin inda gajiya ta bi tsarin da ake iya faɗi. Ko da nawa za a bayyana shine yanke shawara na sirri tare da kasuwanci na gaske, kuma yana hulɗa tare da kariyar aikin da ya bambanta tsakanin hukunce-hukuncen.
Tafiya
Matakan aiki akai-akai waɗanda majiyyata ke ambata sun haɗa da ɗaukar magunguna a cikin kayan hannu tare da takaddun shaida, samun wasiƙar likita don magungunan allura, bincika wuraren kiwon lafiya a wurin da aka nufa, tsara abinci a gaba inda sake kunnawa ke da mahimmanci, da ba da damar dawowa lokacin isowa. Canjin yanayin zafi da tsayi yana da daraja tsammani.
Lafiyar tunani
Rayuwa tare da canzawa, rashin fahimta, kuma akai-akai korar rashin lafiya yana da tsadar hankali na gaske, kuma wannan farashin ba rauni bane na hali. Yawancin marasa lafiya suna kwatanta tsawon lokacin da aka kafirta kafin ganewar asali, wanda ya bar alamarsa. Taimako - ko ƙwararru, ɗan'uwa, ko duka biyu - wani yanki ne mai ma'ana na gudanarwa maimakon shigar da cewa alamomin tunani ne.
- Bambance-bambancen da ya dace a riƙe shi ne: sakin matsakanci na iya haifar da gaske na tashin hankali-kamar ilimin halittar jiki, kuma wannan ya cancanci saninsa maimakon maƙasudin ciwon hauka game da yanayin gaba ɗaya. A lokaci guda, damuwa da damuwa sun zama ruwan dare, ana iya magance su, kuma suna da kyau a magance su da kansu idan akwai.
- Shirye-shiryen gaggawa
- Wasu marasa lafiya masu ciwon mast cell suna cikin haɗarin anaphylaxis - gaggawa, mai tsanani, mai yuwuwar amsawar rayuwa. Inda wannan hadarin ya shafi, tsarawa ba na zaɓi ba ne, kuma tattaunawa ce don yin da likita kafin a buƙaci shi.
- Marasa lafiya da aka tantance kamar yadda suke cikin haɗari galibi ana ba da umarnin epinephrine auto-injectors kuma an shawarce su da su riƙa ɗaukar su akai-akai.
- Epinephrine shine magani na farko don anaphylaxis. Antihistamines ba madadin ba ne kuma bai kamata a dogara da su ba a cikin mummunan hali.
- Rubuce tsarin aikin gaggawa da aka yarda da likitan ku ya kamata ya tsara alamun gargaɗi, abin da za a gudanar, da lokacin kiran sabis na gaggawa.
Marasa lafiya da aka tantance kamar yadda suke cikin haɗari galibi ana ba da umarnin epinephrine auto-injectors kuma an umurce su da ɗaukar su akai-akai. Epinephrine shine jiyya ta farko don anaphylaxis; magungunan antihistamines ba su zama madadinsa ba kuma bai kamata a dogara da shi ba a cikin mummunan hali.
Bayanan kula akan ƙuntata abinci
Ganewar likita da ke lura da ganewar asali da sanannun magunguna yana taimakawa ma'aikatan gaggawa waɗanda ba su da masaniya game da yanayin.
Tiyata da maganin sa barci suna ba da damar tattaunawa gaba don haka za a iya zaɓar wakilai tare da yanayin a hankali.
- Bayanan kula akan ƙuntata abinci
- Tsararren littafin tarihin bayyanar cututtuka na makonni shine hanya mafi aminci don gano abubuwan da ke haifar da mutum.
- Gabatar da bayyanar cututtuka ta tsarin gabobin jiki yana sa tsarin tsarin multisystem ga likitoci.
- Ayyukan yau da kullun suna ɗaga ƙofa kuma suna sa gano abin da zai yiwu.
- Tsararren littafin tarihin bayyanar cututtuka na makonni shine hanya mafi aminci don gano abubuwan da ke haifar da mutum.
- Gabatar da bayyanar cututtuka ta tsarin gabobin jiki yana sa tsarin tsarin multisystem ga likitoci.
Yawan Tambaya Tambayoyi
Tambayoyi 25 marasa lafiya, iyalai, da likitocin asibiti suna yawan yi. Zaɓi kowace tambaya don faɗaɗa ta.
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Shin MCAS na gado ne?
Alamun na iya ingantawa sosai, wani lokaci har zuwa inda marasa lafiya ke bayyana kansu a matsayin masu asymptomatic - musamman da zarar jiyya ta rage matakin mayar da martani kuma an gano manyan abubuwan da ke haifar da su. Ba zato ba tsammani, ƙuduri na dindindin ba tare da wani gudanarwa ba a rubuce sosai. Yawancin lokutan gafara da maimaitawa ana kwatanta su da yawa.
Abubuwa da yawa suna canzawa a kan lokaci: ƙaddamarwa na asali yana motsawa tare da barci, damuwa, yanayin hormonal, da kamuwa da cuta na kwanan nan; Kwayoyin mast na iya sakin nau'ikan masu shiga tsakani daban-daban a lokuta daban-daban; da jawo kafa kansu fadada a lokacin rashin kulawa da kuma sau da yawa kunkuntar sake tare da magani. Canza bayyanar cututtuka halayen yanayin ne maimakon alamar cewa ganewar asali ba daidai ba ne.
Yawancin lokaci don dalilai na fasaha. Masu shiga tsakani da aka auna suna da gajerun rabin rayuwa, don haka samfurin tsakanin halayen bazai sami wani abu mai girma ba. Wasu da yawa kuma ba su da kwanciyar hankali a cikin ɗaki kuma suna buƙatar sanyi cikin gaggawa da aiki cikin gaggawa - samfurin da ya zauna ko aka jinkirta tafiya yana iya karanta al'ada daga mara lafiyar da ke amsawa da gaske.Ana kuma sa ran aikin jini na yau da kullun da na'urorin rashin lafiyan su zama na al'ada a cikin MCAS, tunda ba a tsara su don gano shi ba.
Ee, ta hanyar daftarin tsarin ilimin lissafi. Kwayoyin mast suna ɗaukar masu karɓa don corticotropin-sakin hormone kuma suna zama kusa da ƙarshen jijiyoyi, suna ba da ilimin halin danniya kai tsaye zuwa gare su. Wannan yana da mahimmanci a bayyana a fili, saboda marasa lafiya waɗanda alamun su ke daɗaɗawa a ƙarƙashin damuwa sau da yawa ana gaya wa yanayin yanayin tunani ne. Hanyar neuroimmune ba daidai ba ce da alamar da ake tunanin.
A'a. Canjin abinci zai iya rage nauyin alamun bayyanar cututtuka ga wasu marasa lafiya ta hanyar rage yawan nauyin jawo, kuma wannan amfanin yana da daraja a bi da tunani - amma ba ya warkar da yanayin. Shaida don ƙananan abinci na histamine yana da iyaka kuma yana da inganci mai sauƙi. Tsawaita ƙuntatawa mara kulawa yana ɗauke da haƙiƙanin kasada na ƙarancin abinci mai gina jiki da rashin cin abinci, don haka tsari, ƙayyadaddun gwaji tare da maidowa ya fi aminci fiye da buɗaɗɗen gujewa.
A cikin mastocytosis jiki yana tara ƙwayoyin mast da yawa, kuma za'a iya nunawa fiye da haka - ta hanyar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta, yawanci tare da maye gurbin KIT D816V a cikin cututtukan cututtuka na manya. A cikin MCAS adadin ƙwayoyin mast ɗin al'ada ne; Abin da ba daidai ba shine yadda suke kunnawa cikin sauri. Wannan shine dalilin da ya sa za'a iya tabbatar da mastocytosis ta hanyar gano kwayoyin halitta kuma MCAS ba zai iya ba.
A'a, kodayake suna yawan rikicewa. An kwatanta rashin haƙuri na histamine gabaɗaya azaman wahalar rushe histamine da aka cinye, galibi ana danganta shi da raguwar ayyukan enzyme diamine oxidase. MCAS ya ƙunshi ƙwayoyin mast ɗin jiki suna sakin histamine da sauran masu shiga tsakani da yawa ba daidai ba. Za su iya haifar da bayyanar cututtuka masu rikitarwa kuma suna iya kasancewa tare, amma hanyoyin sun bambanta.
Wannan shi ne daidai inda kwararru ba su yarda ba. Ma'auni na yarjejeniya suna buƙatar tabbataccen shaidar sakin matsakanci, kuma yawancin likitocin sun yi riko da hakan sosai. Wasu suna jayayya cewa ƙaƙƙarfan aikace-aikacen ya ɓace marasa lafiya waɗanda gwajin su akai-akai ya gaza saboda lokuta da dalilai na kulawa. The debate is unresolved in the literature, which is why two competent specialists can reach different conclusions about the same patient.
Allergists da immunologists mafi yawanci, da kuma hematologists inda mastocytosis ne la'akari. A aikace, sabani ya bambanta ko da a cikin waɗancan ƙwararrun, kuma samun dama ga likitocin da ke da gogewar kwayar halitta ba ta dace ba a yanayin ƙasa. Yawancin marasa lafiya suna ganin cewa babban likita mai cikakken bayani yana son daidaita kulawa yana da mahimmanci kamar alƙawari na ƙwararru.
Yawancin lokaci suna taimakawa amma ba kasafai suke warware komai ba, kuma ana sa ran amsawar wani bangare maimakon alamar cutar ta kuskure. Antihistamines suna toshe histamine kawai; prostaglandins, leukotrienes, platelet activating factor, da cytokines ba su da tasiri. Wannan shine ainihin dalilin da yasa jiyya ke karuwa a cikin tiers, yana ƙara wakilai waɗanda ke magance masu shiga tsakani antihistamines.
Biyu gama gari bayani. Wasu nau'ikan magunguna na iya kunna mast cells kai tsaye, ba tare da wata hanyar rashin lafiya ba. Na dabam, abubuwan da ba su da aiki - dyes, fillers, preservatives - na iya zama bangaren tsokana maimakon magungunan da ke aiki, wanda shine dalilin da ya sa majiyyaci na iya jure wa nau'in masana'anta ɗaya kuma ya amsa ga wani. A wasu lokuta ana amfani da shirye-shirye masu haɗaka inda ake zargin hakan.Tattauna duk wani abin da ake zargi da aikatawa tare da likitan ku maimakon tsayawa gaba ɗaya.
Yana iya zama, dangane da tsanani da kuma kan tsarin doka inda kake zama. Wasu marasa lafiya suna aiki da karatu ba tare da gyare-gyare ba; wasu suna da iyaka sosai. Ƙididdigar nakasassu ƙayyadaddun yanki ne kuma gabaɗaya suna buƙatar takaddun tasiri na aiki maimakon ganewar asali kaɗai. Rubutun lissafin likita na iyakoki yawanci ya fi amfani fiye da alamar bincike da kanta.
Shin MCAS nakasa ne?
Abubuwan da aka bayar da rahoton sun bambanta sosai - wasu marasa lafiya suna bayyana ingantawa yayin daukar ciki, wasu suna tabarbarewa, wasu kuma ba su da canji. An rubuta tasirin Hormonal akan sel mast, wanda ke sa canji a kowane bangare ya zama tabbatacce. Ciki tare da MCAS yana ba da garantin ci gaba tare da likitan ku na mast cell da ƙungiyar ku na haihuwa, musamman game da waɗanne magunguna za su ci gaba.
Domin ƙwayoyin mast suna amsawa ga abubuwan motsa jiki kai tsaye, ba kawai ga allergens ba. Zafi, sanyi, matsa lamba, gogayya, da motsa jiki duk na iya kunna su ba tare da wani abu ya shiga jiki ba. An tsara gwajin alerji don gano haɓakawar IgE-matsakaici zuwa takamaiman sunadaran, don haka ba zai iya gano waɗannan abubuwan da ke haifar da rashin lafiyar jiki ba - wanda shine dalilin da ya sa kwamitin rashin lafiyar mai tsabta ya dace gabaɗaya tare da halayen gaske na zafi.
Ya dogara da wakili. Antihistamines sukan nuna tasiri a cikin kwanaki. Mast cell stabilizers irin su cromolyn da ketotifen yawanci suna buƙatar makonni na daidaitaccen amfani kafin cikakken amfaninsu ya bayyana, kuma tsayawa da wuri hanya ce ta gama gari don watsar da wani abu da zai yi aiki. Gwajin kusan makonni huɗu zuwa shida kowane canji shine ƙa'idar babban yatsa da aka ambata akai-akai.
Gabaɗaya a'a, kuma wannan yana ɗaya daga cikin kuskuren sarrafa kai na gama gari. Fara wakilai da yawa tare yana sa sakamakon ya zama wanda ba za a iya fassara shi ba: idan abubuwa sun inganta, ba za ku iya sanin wane canji ne ke da alhakin ba, kuma idan kun amsa, ba za ku iya faɗi abin da za ku daina ba. Canji ɗaya a lokaci guda yana da hankali amma shine abin da ke sa tsarin ya zama abin karantawa.
Yawancin marasa lafiya sun nuna alamun bayyanar cututtuka na kamuwa da cuta, kuma kamuwa da cuta an san shi don kunna mast cells ta hanyar masu karɓa kamar Toll, don haka hanyar da aka tsara yana da kyau. Ko kamuwa da cuta yana haifar da MCAS ba a kafa ba, kuma nuna sanadin a lokuta ɗaya yana da wahala ta hanyar dabara. Game da Dogon COVID musamman, shigar mast cell hasashe ne mai aiki tare da shaida ta farko, ba bincike mai zurfi ba.
Ana yawan gano cutar a cikin mata. Estrogen yana rinjayar halayen mast cell, wanda shine bayanin da aka ba da shawara, kuma yawancin marasa lafiya suna ba da rahoto game da yanayin yanayin yanayi. Ko bambance-bambancen yana nuna yaɗuwar gaskiya ko bambance-bambance a cikin ganewar asali da mai ba da shawara ba a cika warwarewa ba - faɗakarwar da ta shafi yanayi da yawa da aka gano galibi a cikin mata.
Ƙididdiga na gaskiya ba su wanzu ba tukuna. An bayyana yanayin a hukumance kawai a cikin 2007, ana ci gaba da muhawara game da ƙa'idodin bincike, kuma aikin ya bambanta tsakanin ƙasashe. Ƙididdiga da aka buga sun yi yawa sosai, kuma faɗin wannan kewayon shine abin da aka gano. Yi shakku game da ƙwaƙƙwaran ƙididdiga masu yawa daga kowace tushe.
A'a, kuma yunƙurin yin hakan yawanci ba shi da fa'ida. Lissafin da aka buga suna fara hasashe don gwadawa akan rikodin ku, ba dokokin da suka shafi iri ɗaya ba - bambancin mutum yana da yawa, kuma yawancin marasa lafiya suna jure wa abubuwan da ke bayyana akan kowane jeri. Saboda abubuwan da ke jawo tari, sabo da jimillar kaya galibi suna da mahimmanci fiye da kowane abinci guda. Yi aiki zuwa mafi ƙarancin ƙuntatawa wanda ke samun iko.
Tarihin alama wanda tsarin gabobi ya tsara maimakon tsarin lokaci, wanda ke sa tsarin tsarin multisystem ya bayyana nan da nan. Alama da bugun zuciya wanda ke rufe aƙalla makonni biyu. Duk sakamakon gwajin da ya gabata, gami da na yau da kullun, tunda waɗannan sune ɓangaren tsarin cirewa. Jerin magunguna na yanzu da kari.Kuma taƙaitaccen jerin tambayoyinku - alƙawura gajeru ne kuma yana da sauƙin barin ba tare da tambayar abin da ya fi mahimmanci ba.
Ƙarin Koyo Albarkatu
An tsara wuraren farawa don zurfafa karatu. Ana tattara takamaiman hanyoyin haɗin gwiwa kuma za a ƙara su anan.
Jagoran haƙuri
Gabatarwa mai isa da aka rubuta don marasa lafiya da iyalai, dacewa don rabawa tare da mutane sababbi ga yanayin.
- Jagorar mara lafiya na gabatarwa - hanyar haɗi don ƙarawa
- Sabuwar fakitin daidaitawa da aka gano - hanyar haɗi don ƙarawa
- Alamar da za a iya bugawa da samfurin littafin rubutu mai jawo - hanyar haɗi don ƙarawa
- Jagorar mara lafiya na gabatarwa - hanyar haɗi don ƙarawa
Dokokin Likita
Bayanin yarjejeniya da jagorar asibiti da aka yi niyya don ƙwararrun kiwon lafiya. Yana da amfani don kawo alƙawura.
- Jagora ga 'yan uwa da masu kulawa - hanyar haɗi don ƙarawa
- ƙwararrun al'umma jagorar asibiti - hanyar haɗi don ƙarawa
- Gwajin matsakanci da ƙa'idar sarrafa samfurin - hanyar haɗi don ƙarawa
- Ma'aunin bincike na yarjejeniya - ambato da hanyar haɗi don ƙarawa
Takardun Bincike
Adabi na farko. Inda zai yiwu, fi son tushen da aka bita na tsara da kwanan watan bugawa, yayin da wannan filin ke motsawa.
- Takardun haruffa na asali (2007 gaba) - ambaton da za a kara
- Takardun ƙa'idodin yarjejeniya (2010, 2012) - ambaton da za a kara
- Binciken gado na alpha tryptasemia - ambaton da za a kara
- Reviews na alaƙa yanayi - ambaton da za a kara
Ƙungiyoyin Ƙwararru
Ƙungiyoyin ƙwararru da ƙungiyoyin ilimi waɗanda ke aiki akan cutar mast cell.
- Reviews na alaƙa yanayi - ambato da za a kara
- Cibiyoyin bincike na cututtukan ƙwayoyin cuta - hanyoyin da za a kara
- Kungiyoyi masu zaman kansu na cututtuka - hanyoyin da za a kara
Littattafai
Karatu mai tsayi ga marasa lafiya da likitoci.
- Kungiyoyi masu zaman kansu na cututtuka - hanyoyin da za a kara
- Rubutun Magana na asibiti - da za a kara
Karatu mai tsayi ga marasa lafiya da likitoci.
An yi rikodin laccoci, masu bayani, da kayan taro.
- Rubutun Magana na asibiti - da za a kara
- Laccoci na musamman - hanyoyin da za a kara
- Cikakkun bayanai don abun ciki na ilimi na MCAS - hanyoyin da za a kara
Ƙungiyoyin Tallafawa
Taimakon abokan aiki, shawarwari, da al'umma.
- Cikakkun bayanai don abun ciki na ilimi na MCAS - hanyoyin da za a kara
- Al'ummomin tallafi na tsara - hanyoyin da za a kara
- Ƙungiyoyin tallafi na yanki da na ƙasa - hanyoyin da za a kara
Gwajin asibiti
Nazarin da ake ɗauka a halin yanzu. Samuwar gwaji yana canzawa akai-akai, don haka duba lissafin rajista kai tsaye.
- Ƙungiyoyin tallafi na yanki da na ƙasa - hanyoyin da za a kara
- A halin yanzu ana daukar karatun mast cell - hanyoyin da za a kara
- Jagora kan abin da halartar gwaji ya ƙunsa - hanyar haɗi don ƙarawa
A halin yanzu ana daukar karatun mast cell - hanyoyin da za a kara
Mahimman ra'ayoyi daga wannan jagorar, tantace.
- MCAS cuta ce ta kwayar mast ɗin da ba ta dace ba kunnawa, ba na lambobi na mast cell - sel na al'ada ne, bakin kofa ba.
- Mahimman ra'ayoyi daga wannan jagorar, tantace.
- a takaice
- Masu shiga tsakani suna saki a cikin raƙuman ruwa: an riga an kafa su a cikin daƙiƙa, masu shiga tsakani a cikin mintuna, cytokines sama da sa'o'i. Taron kunnawa ɗaya na iya ɗaukar rana ɗaya.
- Kwayoyin mast suna da fa'ida da amfani da ƙwayoyin rigakafi waɗanda aka ajiye a shingen jiki, suna riƙe da masu shiga tsakani da aka riga aka yi a shirye don saki cikin daƙiƙa.
- Alamu na al'ada ne, masu maimaitawa, kuma sun haɗa da tsarin gabobin jiki biyu ko fiye - wannan ƙirar, ba kowane alamar mutum ba, shine abin da ke nuna ganewar asali.
- Masu shiga tsakani suna saki a cikin raƙuman ruwa: an riga an kafa su a cikin daƙiƙa, masu shiga tsakani a cikin mintuna, cytokines sama da sa'o'i. Taron kunnawa ɗaya na iya ɗaukar rana ɗaya.
- Histamine matsakanci ɗaya ne kawai a tsakanin mutane da yawa, wanda shine dalilin da ya sa magungunan antihistamines sukan ba da wani ɓangare maimakon cikakken taimako.
- Masu tayar da hankali. Tarin nauyi yana bayyana halayen da in ba haka ba suna kama da bazuwar, kuma shine mafi amfani ra'ayi guda ɗaya don sarrafa yau da kullun.
- Abubuwan da ke haifar da jiki - zafi, sanyi, matsa lamba, motsa jiki - ba sa buƙatar wani abu da aka ci kuma ba a iya gani ga daidaitaccen gwajin alerji.
- Shigar mast cell shine kafa a kullum urticaria da asma; ƙungiyoyi tare da POTS, hEDS, IBS da Dogon COVID an ba da rahoton amma ba a warware su ba.
- Yawancin gwaje-gwajen matsakanci mara kyau suna nuna lokaci da matsalolin sarrafa samfur maimakon rashin cuta.
- Sharuɗɗan bincike suna ci gaba da hamayya da gaske, don haka ƙwararrun ƙwararrun za su iya cimma matsaya daban-daban game da majiyyaci iri ɗaya.
- Inda haɗarin anaphylaxis ya shafi, epinephrine da rubutaccen shirin aiki suna da mahimmanci; antihistamines ba madadin.
- Ba a kafa dalilin MCAS ba - bi da'awar 'tushen dalili' tare da shakku.
Kamus
Kalmomi 91 da aka yi amfani da su a cikin adabi na MCAS da tattaunawa ta asibiti, an bayyana su a sarari.