Zvishandiso - Kuongororwa
Chiyero
Kutanga, chiratidzo chechiratidzo. Zviratidzo zvinofanirwa kudzokororwa uye episodic, uye zvinofanirwa kusanganisira maviri kana anopfuura enhengo masisitimu. Misanganiswa yakajairika inosanganisira ganda rine gastrointestinal, kana moyo nevascular nekufema. Dambudziko rakaganhurirwa kune imwe sisitimu, kana iyo inogara iripo kwete kuchinjika, haikodzeri.
Chechipiri, humbowo hwechinangwa chekusunungurwa kwemast cell mediator. Izvi zvinoreva kuyerwa kwerabhoritari - kazhinji kukwira kweserum tryptase panguva yechiitiko zvichienzaniswa nemurwere pachake-isina chiratidzo chekutanga, kana yakakwirisa muyananisi metabolites muweti. Chikumbaridzo chetryptase mukushandiswa kwakajairwa kukwira kweinenge 20% pamusoro pekutanga pamwe nekuwedzera 2 ng/mL.
Chechitatu, mhinduro kumushonga wakananga mast cells. Kuvandudzwa kweH1 uye H2 antihistamines, mast cell stabilizers, kana maajenti ane hukama anotsigira kuongororwa. Ichi chiyero chinotakura huremu chaihwo mukuita, kunyanya apo kuyedzwa kwemuyananisi kwave kusingaite.
Padivi peizvi, mamwe mamiriro anokwanisa kuburitsa mufananidzo mumwe chete haafanire kuverengerwa - kusanganisira mastocytosis, iyo inosanganisira kuwanda chaiko kwemaseru maseru uye inoferefetwa zvakasiyana. Ziva kuti misiyano yegadziriro iyi iripo uye nyanzvi dzinosiyana pamashandisiro avanoita chirevo chechipiri; maitiro emukiriniki anogona kusiyana nezviri kutsanangurwa pano.
Zvose zvitatu zvinodiwa, pamwe chete. Yechipiri - humbowo hwechinangwa - ndipo panogara nzendo dzakawanda dzekuongorora, uye kazhinji nekuda kwezvikonzero zvehunyanzvi kwete nekuti murwere haana mamiriro acho.
Serum tryptase ndicho chicherechedzo chakasimbiswa. Zvinoda zviyero zviviri kuti zvidudzirke: imwe inotorwa panguva kana nguva pfupi mushure mekuita, uye imwe inotorwa pakutanga kana zviratidzo zvanyarara. Chinhu chimwechete chakazvimiririra chinonetsa kuita pachiri, nekuti chakakosha ishanduko kubva pahwaro hwekutanga kwete nhamba yakakwana.Muenzaniso wakaoma unofanirwa kukweverwa mukati meawa imwe kusvika mana yekutanga maitiro, uye yekutanga sampu ingangoita maawa makumi maviri nemana mushure mekunge zviratidzo zvagadzikana.
24-awa yekuunganidza weti kuyera murevereri metabolites - kazhinji N-methylhistamine, prostaglandin D2 kana metabolite yayo 11-beta-prostaglandin F2-alpha, uye leukotriene E4. Aya anotora hwindo rakareba pane kudhirowa ropa rimwe chete uye anogona kuona activation ingapotsa snapshot. Vanofanira kutanga panguva yezviratidzo.
Serum tryptase ndicho chicherechedzo chakasimbiswa. Zvinoda zviyero zviviri kuti zvidudzirke: imwe inotorwa panguva kana nguva pfupi mushure mekuita, uye imwe inotorwa pakutanga kana zviratidzo zvanyarara. Chinhu chimwechete chakazvimiririra chinonetsa kuita pachiri, nekuti chakakosha ishanduko kubva pahwaro hwekutanga kwete nhamba yakakwana.Muenzaniso wakaoma unofanirwa kukweverwa mukati meawa imwe kusvika mana yekutanga maitiro, uye yekutanga sampu ingangoita maawa makumi maviri nemana mushure mekunge zviratidzo zvagadzikana.
Nekuda kweizvi, zvakakosha kusimbisa iyo yekubata protocol neanoraira chiremba uye murabhoritari pamberi muunganidzwa kwete mushure memhedzisiro isingatarisirwe. Haisi yega yega marabhoritari inogaroita aya mayedzo, uye haisi yega yega kit yekuunganidza inosvika ine mirairo yakakwana.
Usati Waedza
Dudziro
Iwo maedzo anoyera makemikari ane pfupi hafu yeupenyu. Trypase inokwira mukati memaawa mashoma ekuita uye yobva yadonha; urinary metabolites inopfuurira kwenguva refu asi ichiri kuratidza hwindo shoma. Kana muenzaniso ukatorwa pakati pezvikamu, panogona kunge pasina chinhu chakakwirira kuwana - kwete nekuti activation haina kumboitika, asi nekuti haichayereki.
Muyedzo wemurevereri wakashata hausi wega kunze kweMCAS - uye kunzwisisa kuti nei ichidzivirira kuodzwa mwoyo kwakanyanya kusingakoshi.
Iwo maedzo anoyera makemikari ane pfupi hafu yeupenyu. Trypase inokwira mukati memaawa mashoma ekuita uye yobva yadonha; urinary metabolites inopfuurira kwenguva refu asi ichiri kuratidza hwindo shoma. Kana muenzaniso ukatorwa pakati pezvikamu, panogona kunge pasina chinhu chakakwirira kuwana - kwete nekuti activation haina kumboitika, asi nekuti haichayereki.
Matambudziko ekubata anotsanangurwa pamusoro apa anowedzera izvi. Pakati pekuunganidza kwakashata uye masampuli akaderedzwa, chikamu chakakura chemhedzisiro yakaipa mumabhuku uye mumaakaundi evarwere kukanganisa kwehunyanzvi pane kusavapo kwechirwere.
Hapana chimwe cheizvi chinoreva kuti kuyedzwa kunofanira kuregwa. Humbowo hwechinangwa hunosimbisa kuongororwa zvakanyanya, hunovhura mukana wekurapwa, uye nyaya dzeinishuwarenzi nepekugara. Zvinoreva kuti mhedzisiro inofanirwa kukurudzira hurukuro nezve nguva uye kubata - uye pamwe kudzokorora kuedza panguva yekupindura - pane kuvhara mubvunzo.
Hunza nhoroondo yechiratidzo yakanyorwa yakarongwa neorgan system pane kutevedzana kwezviitiko. Kunyora ganda, gastrointestinal, yemwoyo, kufema, uye neurological zviratidzo semapoka zvinoita kuti multisystem pateni ionekwe nekukasira, uko nhoroondo yenhoroondo inowanzoivhara.
Hunza dhayari rako rekutanga kana wakachengeta imwe - ona Zvikonzero kuti chii kunyora. Zvikamu zvakanyorwa zvine nguva uye kuomarara zvinopa murapi chimwe chinhu chakasimba chekushanda kubva, uye kubatsira kumisikidza episodic pateni inodiwa yekutanga.
Huyai nemiyedzo yekutanga, kusanganisira isina kunaka. Zvakajairwa allergy mapaneru, zvisingashamisi endoscopies, uye akajeka emwoyo workups ane ruzivo: iwo ari chikamu chemaitiro ekusarudzika, uye anochengetedza kudzokorora kwemiedzo yatoitwa.
Bvunza zvakananga nezve muyananisi yekuyedza nguva uye sampuli kubata. Mubvunzo unonzwisisika, unoratidza kuti unonzwisisa maitiro, uye unovandudza mukana wemhedzisiro inoshandisika.
Huyai nemiyedzo yekutanga, kusanganisira isina kunaka. Zvakajairwa allergy mapaneru, zvisingashamisi endoscopies, uye akajeka emwoyo workups ane ruzivo: iwo ari chikamu chemaitiro ekusarudzika, uye anochengetedza kudzokorora kwemiedzo yatoitwa.